Home » Diseases » Botulism: Disease Bioinformatics
Submit your image related to Diseases to be featured!
Submit an Image

Get Social

Submit your Twitter account related to Botulism to be featured!
Submit an Account

Blogs

 Submit your blog on Botulism to be featured!
Submit a Blog

Events

 Submit your event on Botulism to be featured!
Submit an Event

Videos

Submit your video on Botulism to be featured!
Submit a Video

Charities

Submit your charity on Botulism to be featured!
Submit a Charity

Botulism: Disease Bioinformatics

Botulism, caused by a nerve toxin, is a very rare but serious condition that causes paralysis. The nerve toxin is caused by Clostridium botulinum which is a type of bacteria that can be found in the soil and low-oxygenated areas. There are three common types of botulism. Occurring in about 15% of cases, Foodborne botulism is caused by botulinum toxin contaminated foods. Occurring about 20% of the time, Wound botulism is caused when a wound is infected with the bacteria and then the toxin is produced. Infant botulism, occurring 65% of the time, is caused when the infant consumes the bacteria which then grows in their intestines and releases the toxin. Symptoms of botulism include muscle weakness, dry mouth, and double vision. Botulism is treated with antitoxins and antibiotics, and the death rate due to botulism has dropped from 50% to 3-5% in the last 50 years.

Botulism Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Botulism below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 850 products for the study of Botulism that can be applied to Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

GPHA2 Antibody
NBP3-17255
Western Blot: GPHA2 Antibody [NBP3-17255] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10; Lane 2: RT4; Lane 3: U-251 MG; Lane 4: Human Plasma; Lane 5: Liver; Lane 6: TonsilImmunocytochemistry/Immunofluorescence: GPHA2 Antibody [NBP3-17255] - Staining of human cell line Hep G2 shows localization to vesicles.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF

Arylsulfatase A/ARSA Antibody
NBP1-00154
Western Blot: Arylsulfatase A/ARSA Antibody [NBP1-00154] - Western blot analysis of Mouse testes lysate (A) + peptide (B) with antibody at 1 ug/mL and Rat testes lysate (C) + peptide (D) with antibody at 0.3 ug/mL, 35ug protein in RIPA buffer. Detected by chemiluminescence.Immunocytochemistry/Immunofluorescence: Arylsulfatase A/ARSA Antibody [NBP1-00154] - Immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL), showing Golgi apparatus staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (2 ug/mL).

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

1 Publication
MAP4K6 Antibody
NBP1-22990
Western Blot: MAP4K6 Antibody [NBP1-22990] - Wole cell lysate from HeLa and mouse NIH3T3 cells at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IP

5 Publications
KCNE1 Antibody (5B12)
H00003753-M01
Western Blot: KCNE1 Antibody (5B12) [H00003753-M01] - Analysis of KCNE1 over-expressed 293 cell line, cotransfected with KCNE1 Validated Chimera RNAi ( Cat # H00003753-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with KCNE1 monoclonal antibody (M01), clone 5B12 (Cat # H00003753-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.Western Blot: KCNE1 Antibody (5B12) [H00003753-M01] - analysis of KCNE1 expression in transfected 293T cell line by KCNE1 monoclonal antibody (M01), clone 5B12. Lane 1: KCNE1 transfected lysate (14.7 KDa). Lane 2: Non-transfected lysate.

Mouse Monoclonal
Species Human, Rat, Canine
Applications WB, ELISA, ICC/IF

2 Publications
Clathrin Heavy Chain 1/CHC17 Antibody (X22) - BSA Free
NB300-613
Western Blot: Clathrin Heavy Chain 1/CHC17 Antibody (X22) [NB300-613] - Analysis of 25 ug of human brain lysates.Immunocytochemistry/Immunofluorescence: Clathrin Heavy Chain 1/CHC17 Antibody (X22) [NB300-613] - Analysis of Clathrin, Heavy chain using Anti-Clathrin, Heavy chain Monoclonal Antibody (X22) shows staining in Hela Cells. Clathrin, Heavy chain staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing Clathrin, Heavy chain at a dilution of 1:200 over night at 4C, washed with PBS and incubated with a DyLight-488 conjugated secondary antibody. Images were taken at 60X magnification.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

     1 Review

7 Publications
DEGS1 Antibody
NBP1-59941
Western Blot: DEGS1 Antibody [NBP1-59941] - Positive control (+): 293T (2T). Negative control (-): MCF7 (N10). Antibody concentration: 1ug/mlImmunohistochemistry: DEGS1 Antibody [NBP1-59941] - Human Lung Tissue Observed Staining: Cytoplasm of pneumocytes Primary Antibody Concentration: 1 : 600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1 : 200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

FMN1 Antibody (4F4)
H00342184-M07
Western Blot: FMN1 Antibody (4F4) [H00342184-M07] - Analysis of FMN1 expression in Jurkat.Immunocytochemistry/Immunofluorescence: FMN1 Antibody (4F4) [H00342184-M07] - Analysis of monoclonal antibody to FMN1 on HeLa cell. Antibody concentration 10 ug/ml

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

ARHGAP4 Antibody
NBP1-88527
Immunohistochemistry-Paraffin: ARHGAP4 Antibody [NBP1-88527] - Staining in human spleen and cerebral cortex tissues using anti-ARHGAP4 antibody. Corresponding ARHGAP4 RNA-seq data are presented for the same tissues.Immunohistochemistry-Paraffin: ARHGAP4 Antibody [NBP1-88527] - Staining of human colon, liver, lymph node and testis using Anti-ARHGAP4 antibody NBP1-88527 (A) shows similar protein distribution across tissues to independent antibody NBP1-88528 (B).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

SNAP25 Antibody
NBP1-88769
Immunohistochemistry-Paraffin: SNAP25 Antibody [NBP1-88769] - Analysis in human cerebral cortex and testis tissues using NBP1-88769 antibody. Corresponding SNAP25 RNA-seq data are presented for the same tissues.Western Blot: SNAP25 Antibody [NBP1-88769] - Analysis in human cell lines U2OS and MCF-7 using anti-SNAP25 antibody. Corresponding SNAP25 RNA-seq data are presented for the same cell lines. Loading control: anti-GAPDH.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-P

4 Publications
ATP6V0A1 Antibody
NBP1-89342
Immunohistochemistry-Paraffin: ATP6V0A1 Antibody [NBP1-89342] - Analysis in human cerebral cortex and tonsil tissues. Corresponding ATP6V0A1 RNA-seq data are presented for the same tissues.Western Blot: ATP6V0A1 Antibody [NBP1-89342] - In Cln1-/- mice V0a1 is misrouted to plasma membrane preventing its interaction with AP-3. Pull-down assay with AP-3 antibody using total lysates from untreated (lane 1) and bromopalmitate-treated (lane 2) WT brain slices to detect V0a1 and its densitometric quantitation (n=4, *P<0.05). HEK-293 cells were transfected with WT GFP-V0a1 and GFP-V0a1-Cys25Ser mutant construct, and pull-down experiments were conducted with AP-3 antibody to detect GFP-V0a1,*P<0.05(n=4). Image collected and cropped by CiteAb from the following publication (http://www.nature.com/doifinder/10.1038/ncomms14612), licensed under a CC-BY licence.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

     1 Review

5 Publications
VAMP-2 Antibody
NB300-595
Western Blot: VAMP-2 Antibody [NB300-595] - Analysis was performed on tissues (40 ug lysate) of Mouse Cerebellum (Lane 1), Mouse Brain (Lane 2) and Rat Brain (Lane 3). Flow Cytometry: VAMP-2 Antibody [NB300-595] - Cells were fixed with 70% ethanol for 10 minutes, permeabilized with 0.25% Triton™ X-100 for 20 minutes, and blocked with 5% BSA for 30 minutes at room temperature.

Rabbit Polyclonal
Species Mouse, Rat, Bovine
Applications WB, Flow, IHC

4 Publications
RFC1 Antibody [Unconjugated]
AF6457
Western blot shows lysates of Daudi human Burkitt's lymphoma cell line. Gels were loaded with 30 µg of whole cell lysate (WCL), 20 µg of cytoplasmic (Cyto), and 10 µg of nuclear extracts (Nuc).  PVDF Membrane was probed with 1 µg/mL of Sheep Anti-Human RFC1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6457) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <a class=

Sheep Polyclonal
Species Human
Applications WB

FoxC2 Antibody
AF6989
FoxC2 was detected in immersion fixed frozen sections of mouse embryo (E15.5) using Sheep Anti-Mouse FoxC2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6989) at 10 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red; Catalog # <A class=NoLineLink href=

Sheep Polyclonal
Species Mouse
Applications IHC

8 Publications
hnRNP C1 + C2 Antibody (CL2593)
NBP2-36776
Western Blot: hnRNP C1 + C2 Antibody (CL2593) [NBP2-36776] - Analysis in U-251MG cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-HNRNPC antibody. Remaining relative intensity is presented. Loading control: Anti-PPIB.Immunocytochemistry/Immunofluorescence: hnRNP C1 + C2 Antibody (CL2593) [NBP2-36776] - Staining in U2OS cell line with Anti-HNRNPC monoclonal antibody, showing distinct nuclear (without nucleoli) staining in green. Microtubule- and nuclear probes are visualized in red and blue respectively (where available). Antibody staining is shown in green.

Mouse Monoclonal
Species Human
Applications WB, ICC/IF, IHC

RFC4 Antibody (OTI1A8)
NBP2-45946
Western Blot: RFC4 Antibody (OTI1A8) [NBP2-45946] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RFC4.Immunocytochemistry/Immunofluorescence: RFC4 Antibody (OTI1A8) [NBP2-45946] - Analysis of COS7 cells transiently transfected by pCMV6-ENTRY RFC4.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

Synaptotagmin 2 Antibody
NB100-91297
Immunohistochemistry: Synaptotagmin 2 Antibody [NB100-91297] - IHC on rat spinal cord using Rabbit antibody to Synaptotagmin 2 (80-130) at 1 : 3000 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the immunostaining (not shown).Immunohistochemistry: Synaptotagmin 2 Antibody [NB100-91297] - IHC on rat spinal cord using Rabbit antibody to rat, mouse Synaptotagmin-2: whole serum at 1:3000 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the immunostaining (not shown).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

alpha-Sarcoglycan Antibody (JA51-81)
NBP2-67150
Western Blot: alpha-Sarcoglycan Antibody (JA51-81) [NBP2-67150] - Western blot analysis of alpha-Sarcoglycan on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (1/500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:5,000 dilution was used for 1 hour at room temperature. Positive control: Lane 1: mouse heart tissue lysate Lane 2: human skeletal muscle tissue lysateImmunohistochemistry-Frozen: alpha-Sarcoglycan Antibody (JA51-81) [NBP2-67150] - Human skeletal muscle tissue. IHC-Fr image submitted by a verified customer review.

Rabbit Monoclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-Fr

     1 Review

RFC2 Antibody (OTI2B2) - Azide and BSA Free
NBP2-73857
Western Blot: RFC2 Antibody (OTI2B2) - Azide and BSA Free [NBP2-73857] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RFC2.Immunohistochemistry: RFC2 Antibody (OTI2B2) - Azide and BSA Free [NBP2-73857] - Analysis of Human prostate tissue.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, IHC

PFDN4 Antibody
NBP2-93935
Western Blot: PFDN4 Antibody [NBP2-93935] - Analysis of extracts of various cell lines, using PFDN4 at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit . Exposure time: 90s.Immunocytochemistry/Immunofluorescence: PFDN4 Antibody [NBP2-93935] - Analysis of C6 cells using PFDN4 at dilution of 1:100. Blue: DAPI for nuclear staining.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF


Related Genes

Botulism has been researched against:

Related Pathways

Botulism has been linked to:

Related Diseases

Botulism has been studied in relation to diseases such as:

Related PTMs

Botulism has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Botulism is also known as botulism, intoxication with clostridium botulinum toxin, food poisoning due to clostridium botulinum, infection due to clostridium botulinum, foodborne botulism (subtype), infant botulism (subtype), wound botulism (subtype), botulism (disorder), botulism poisoning, foodborne botulism, infection.