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Achlorhydria: Disease Bioinformatics

Achlorhydria is an absence of or reduction in hydrochloric acid in the gastric juice. The decreased acid level itself impairs protein digestion by inhibiting the activation of the enzyme pepsin, whose activation is dependent upon a low gastric pH. Low acid levels in the stomach are linked with bacterial overgrowth the stomach does not kill microbes normally present in food, which can manifest as diarrhea or decreased absorption of nutrients or vitamins. Risk of particular infections, such as Vibrio vulnificus witch commonly from seafood) is increased. Even without bacterial overgrowth, low stomach acid can lead to nutritional deficiencies through malabsorption of basic electrolytes and vitamins including vitamin C, vitamin K, and the B complex of vitamins. Such deficiencies may be involved in the development of a wide range of pathologies, from fairly benign neuromuscular issues to life-threatening diseases. A person with achlorhydria can suffer from stomach pains caused by the digestion of food that is not properly broken down by gastric acid.

Achlorhydria Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Achlorhydria below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 1193 products for the study of Achlorhydria that can be applied to Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

H00002520-P01
12.5% SDS-PAGE Stained with Coomassie Blue.


Species Human

2 Publications
NBP1-81610
Western Blot: GIF Antibody [NBP1-81610] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunohistochemistry-Paraffin: GIF Antibody [NBP1-81610] - Staining of human stomach shows strong cytoplasmic positivity in parietal cells.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

     1 Review

NBP1-05163
Immunocytochemistry/Immunofluorescence: VIP Antibody (2) [NBP1-05163] - Staining in human pancreas tissue. Signal is strong in nerves of exocrine part of pancreas. Dilution: 1:100.Immunohistochemistry-Paraffin: VIP Antibody (2)  - BSA Free [NBP1-05163] - Formalin fixed paraffin-embedded human pancreas tissue. Dilution: 1:100

Mouse Monoclonal
Species Human, Rat, Porcine
Applications WB, ELISA, ICC/IF

NBP2-48988
Immunohistochemistry: Secretin Antibody [NBP2-48988] - Staining of human duodenum shows strong cytoplasmic positivity in endocrine cells.

Rabbit Polyclonal
Species Human
Applications IHC

MAB2358
Somatostatin was detected in immersion fixed human embryonic stem cells differentiated to pancreatic cells using Rat Anti-Human Somatostatin Monoclonal Antibody (Catalog # MAB2358) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rat IgG Secondary Antibody (red; Catalog # <a class=Somatostatin was detected in immersion fixed  beta TC‑6 mouse beta cell insulinoma cell line using Rat Anti-Human Somatostatin Monoclonal Antibody (Catalog # MAB2358) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Rat IgG Secondary Antibody (red; Catalog # <a class=

Rat Monoclonal
Species Human, Mouse
Applications IHC, ICC

AF457
CCL21/6Ckine was detected in perfusion fixed frozen sections of mouse thymus using Goat Anti-Mouse CCL21/6Ckine Antigen Affinity-purified Polyclonal Antibody (Catalog # AF457) at 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # <A class=NoLineLink href=D3 mouse embryonic stem cell line was stained with Goat Anti-Mouse CCL21/6Ckine Antigen Affinity-purified Polyclonal Antibody (Catalog # AF457, filled histogram) or control antibody (Catalog # <A class=NoLineLink href=

Goat Polyclonal
Species Mouse
Applications WB, IHC, CyTOF-ready

     2 Reviews

30 Publications
NB100-62239
Immunohistochemistry-Paraffin: Pepsinogen I Antibody (8003 (99/12)) [NB100-62239] - Differentiation of pyloric-gland type to fundic glands. (A) HE-stained image, showing proliferation of atypical glands associated with mildly enlarged nuclei. (B) Differentiation into fundic glands (pepsinogen-1). Tumor glands are positive for pepsinogen-1. (C) Differentiation into fundic glands (H,K-ATPase). Similar to pepsinogen-1, H,K-ATPase-positive cells can be seen in tumor glands. From: Mitsuishi T, Hamatani S, Hirooka S, Fukasawa N, Aizawa D, Hara Y, et al. (2017)

Mouse Monoclonal
Species Human
Applications ELISA, IHC-P, RIA

MAB9350
Western Blot: Pepsinogen A Antibody (961902) [MAB9350] - Analysis of human stomach tissue lysate with 2 ug/ml of hPGA-4 Monoclonal Antibody followed by HAF005. A specific band was detected for hPGA-4 at approximately45 kDA (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.Immunohistochemistry: Pepsinogen A Antibody (961902) [MAB9350] - Pepsinogen A was detected in immersion fixed paraffin-embedded sections of human stomach using Pepsinogen A Monoclonal Antibody at 1.7 ug/ml. Tissue was stained using Rat IgG VisUCyte HRP Polymer Antibody (brown) and counterstained with hematoxylin (blue). Specific staining was localized to the cytoplasm in epithelial cells.

Rat Monoclonal
Species Human
Applications WB, IHC, IHC-P

     1 Review

8457-AS


Species Human

NB100-1793
Immunohistochemistry-Paraffin: Pancreatic Polypeptide/PP Antibody [NB100-1793] - (5 ug/ml) staining of paraffin embedded Human Intestine. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.Immunohistochemistry-Frozen: Pancreatic Polypeptide/PP Antibody [NB100-1793] - IHC analysis of Pancreatic Polypeptide in mouse adult pancreas tissue. Image courtesy of anonymous customer product review.

Goat Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-Fr

     3 Reviews

10 Publications
NB110-82375
Western Blot: Mucolipin 1 Antibody [NB110-82375] - Detection of Mucolipin-1 in mouse brain lysates using NB110-82375.Simple Western: Mucolipin 1 Antibody [NB110-82375] - Simple Western lane view shows a specific band for Mucolipin 1 in 0.5 mg/ml of Human Brain lysate.  This experiment was performed under reducing conditions using the 12-230 kDa separation system.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western

     1 Review

MAB8864
GIP was detected in immersion fixed paraffin-embedded sections of human stomach using Mouse Anti-Human GIP Monoclonal Antibody (Catalog # MAB8864) at 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # <a class=

Mouse Monoclonal
Species Human
Applications IHC

NB120-14817

Mouse Monoclonal
Species Human, Rat
Applications WB, ICC/IF, IHC

     1 Review

3 Publications
NB100-2803
Western Blot: Cholecystokinin-B R/CCKBR Antibody [NB100-2803] - (1ug/ml) staining of Mouse Pancreas lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry-Paraffin: Cholecystokinin-B R/CCKBR Antibody [NB100-2803] - Staining of paraffin embedded Human Uterus. Steamed antigen retrieval with citrate buffer pH 6, AP-staining

Goat Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

2 Publications
NBP2-34260
Immunohistochemistry-Paraffin: Insulin Antibody (E2-E3 (same as INS04)) [NBP2-34260] - Formalin-fixed, paraffin-embedded human pancreas stained with insulin Monoclonal Antibody (E2-E3)SDS-Page: Insulin Antibody (E2-E3 (same as INS04)) [NBP2-34260]

Mouse Monoclonal
Species Human, Mouse, Porcine
Applications WB, Flow, ICC/IF

     4 Reviews

MAB1249
Glucagon was detected in immersion fixed beta TC-6 mouse beta cell insulinoma cell line using 10 µg/mL Human/Mouse Glucagon Monoclonal Antibody (Catalog # MAB1249) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # <A class=     beta TC‑6  mouse beta cell insulinoma cell line was stained with Mouse Anti-Human/Mouse  Glucagon Monoclonal Antibody (Catalog # MAB1249, filled histogram) or isotype  control antibody (Catalog # <a class=

Mouse Monoclonal
Species Human, Mouse
Applications CyTOF-ready, ICC, ICFlow

     2 Reviews

3 Publications
NBP1-35641
Western Blot: Cholecystokinin Antibody [NBP1-35641] BrainImmunohistochemistry-Paraffin: Cholecystokinin Antibody [NBP1-35641] - Human Stomach

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

NB100-1481
Western Blot: FLVCR Antibody [NB100-1481] - (0.1ug/ml) staining of Human Bone Marrow lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Goat Polyclonal
Species Human
Applications WB, PEP-ELISA

     1 Review

2 Publications