VEGF R2/KDR/Flk-1 Products

Antibodies
VEGF R2/KDR/Flk-1 Antibody
VEGF R2/KDR/Flk-1 Antibody
AF644
Species: Mu
Applications: WB, Flow, IHC, CyTOF-ready, Neut
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
VEGF R2/KDR/Flk-1 Antibody
VEGF R2/KDR/Flk-1 Antibody
NB100-627
Species: Hu, Mu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
VEGF R2/KDR/Flk-1 Antibody [U ...
VEGF R2/KDR/Flk-1 Antibody [Unconj...
AF357
Species: Hu
Applications: WB, IHC, Neut
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
ELISA Kits
VEGF R2/KDR/Flk-1 ELISA Kit
VEGF R2/KDR/Flk-1 ELISA Kit
NBP1-83729
Species: Hu
Applications: ELISA
VEGF R2/KDR/Flk-1 ELISA Kit [ ...
VEGF R2/KDR/Flk-1 ELISA Kit [Biotin]
KA2221
Species: Hu
VEGF R2/KDR/Flk-1 ELISA Kit [ ...
VEGF R2/KDR/Flk-1 ELISA Kit [HRP]
KA2146
Species: Hu
Lysates
VEGF R2/KDR/Flk-1 Overexpress ...
VEGF R2/KDR/Flk-1 Overexpression L...
NBL1-06701
Applications: WB
Proteins
Recombinant Human VEGF R2/KDR ...
Recombinant Human VEGF R2/KDR/Flk-...
NBP1-99411
Species: Hu
VEGF R2/KDR/Flk-1 Blocking Pe ...
VEGF R2/KDR/Flk-1 Blocking Peptide
NB100-2382PEP
Species: Hu
Recombinant Human VEGF R2/KDR ...
Recombinant Human VEGF R2/KDR/Flk-...
P3871
Species: Hu
Applications: Func, PAGE
RNAi
VEGF R2/KDR/Flk-1 RNAi
VEGF R2/KDR/Flk-1 RNAi
H00003791-R04
Species: Hu
Applications: RNAi, RNAi SP

Description

Vascular endothelial growth factor receptor 2 (VEGFR2) is a member of a receptor tyrosine kinase family whose activation plays an essential role in a large number of biological processes such as embryonic development, wound healing, cell proliferation, migration and differentiation. Like other common growth factor receptors, VEGF receptor 2 dimerises upon ligand binding and is autophosphorylated at multiple tyrosine residues. These sites can be involved in the regulation of kinase activity or can serve as binding sites for SH2 and phosphotyrosine binding containing signaling proteins. Phosphorylation of Tyrosines 1054 and 1059 in the activation loop is required for activation of VEGF receptor 2 and its intrinsic tyrosine kinase activity.

Defects in the VEGFR2 gene are associated with susceptibility to benign, highly proliferative lesions involving aberrant localized growth of capillary endothelium called hemangioma capillary infantile. HCI is the most common tumor found in infants, found in up to 10% of all births.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Mouse
Product By Gene ID 3791
Alternate Names
  • fetal liver kinase-1
  • EC 2.7.10
  • EC 2.7.10.1
  • Kinase insert domain receptor
  • Protein-tyrosine kinase receptor flk-1
  • CD309 antigen
  • Fetal liver kinase 1
  • VEGFR-2
  • VEGFR2
  • FLK-1
  • VEGFR
  • vascular endothelial growth factor receptor 2
  • CD309
  • FLK1tyrosine kinase growth factor receptor
  • soluble VEGFR2
  • kinase insert domain receptor (a type III receptor tyrosine kinase)

Research Areas for VEGF R2/KDR/Flk-1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cellular Markers
Endothelial Cell Markers
Hematopoietic Stem Cell Markers
HIF Target Genes
Hypoxia
Phospho-Specific
Signal Transduction
Stem Cell Markers
Tumor Suppressors
Tyrosine Kinases

Bioinformatics Tool for VEGF R2/KDR/Flk-1

Discover related pathways, diseases and genes to VEGF R2/KDR/Flk-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related VEGF R2/KDR/Flk-1 Blog Posts

Check out the latest blog posts on VEGF R2/KDR/Flk-1.
HIF-3 alpha: a versatile target with hypoxia dependent and independent functions
By: Subhash GangarHIF-3 alpha (hypoxia-inducible factor 3-alpha/ HIF3A) represents an isoform of HIF-alpha subunits which heterodimerize with stable beta subunit (HIF-beta) for the regulation of HIF target genes through binding to hypoxia respon...    Read more.
VEGFR-2 - A highly active kinase
VEGFR-2 is a family member of the vascular endothelial growth factor (VEGF) family of membrane receptor tyrosine kinases. It is a key regulator of the process of angiogenesis that takes place during fundamental developmental processes such as embry...    Read more.
Read more VEGF R2/KDR/Flk-1 related blogs.