TTF1 / NKX2.1 Products

Antibodies
TTF1 / NKX2.1 Antibody
TTF1 / NKX2.1 Antibody
NBP2-41160
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC-P
Host: Rabbit Polyclonal
TTF1 / NKX2.1 Antibody
TTF1 / NKX2.1 Antibody
NBP1-19719
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
TTF1 / NKX2.1 Overexpression ...
TTF1 / NKX2.1 Overexpression Lysat...
H00007080-T01
Species: Hu
Applications: WB
TTF1 / NKX2.1 Overexpression ...
TTF1 / NKX2.1 Overexpression Lysat...
NBL1-13658
Applications: WB
TTF1 / NKX2.1 Overexpression ...
TTF1 / NKX2.1 Overexpression Lysat...
NBP2-11446
Applications: WB
Proteins
TTF1 / NKX2.1 Recombinant Pro ...
TTF1 / NKX2.1 Recombinant Protein
H00007080-P01
Species: Hu
Applications: WB, ELISA, PA
TTF1 / NKX2.1 Partial Recombi ...
TTF1 / NKX2.1 Partial Recombinant ...
H00007080-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
TTF1 / NKX2.1 RNAi
TTF1 / NKX2.1 RNAi
H00007080-R01
Species: Hu

Description

The thyroid transcription factor 1 (TTF-1) is a homeodomain-containing transcription factor that activates the transcriptional activity of thyroid-specific gene promoters by binding to them. Hence, TTF-1 is crucial in the maintenance of the thyroid differentiation phenotype (1). Thyroid dysgenesis (TD) is responsible for most cases of congenital hypothyroidism, a condition that affects about one in 4000 newborns. Mutations in PAX8, TTF1, or FOXE1 may account for congenital hypothyroidism in patients with either isolated TD or TD with associated malformations involving kidney, lung, forebrain, and palate (2). In addition to its presence in thyroid gland epithelium, the human TTF-1 protein was detected by immunohistochemistry in human fetal lung as early as 11 weeks of gestation, being localized in the nuclei of epithelial cells of the developing airways. After birth, TTF-1 was selectively expressed in Type II epithelial cells in the alveoli and in subsets of bronchiolar epithelial cells in the conducting regions of the lung (3).

Bioinformatics

Entrez Human
Mouse
Mouse
Mouse
Rat
Rat
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Rat
Product By Gene ID 7080
Alternate Names
  • TTF1
  • NK-2 homolog A
  • Thyroid nuclear factor 1
  • homeobox protein Nkx-2.1
  • Homeobox protein NK-2 homolog A
  • TITF1TEBP
  • NKX2ANKX2.1
  • TTF-1NK-2
  • Thyroid transcription factor 1BHC
  • TTF1BCH
  • benign chorea
  • NK2 homeobox 1

Research Areas for TTF1 / NKX2.1

Find related products by research area and learn more about each of the different research areas below.

Membrane Trafficking and Chaperones

PTMs for TTF1 / NKX2.1

Learn more about PTMs related to TTF1 / NKX2.1.

Methylation
Phosphorylation
Demethylation
Acetylation

Bioinformatics Tool for TTF1 / NKX2.1

Discover related pathways, diseases and genes to TTF1 / NKX2.1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related TTF1 / NKX2.1 Blog Posts

Check out the latest blog posts on TTF1 / NKX2.1.
TTF1 / NKX2.1 - An essential regulator of lung development with implications in cancer diagnostics
Thyroid transcription factor 1 (TTF-1), also known as NKX2.1, is a conserved master regulatory transcription factor involved in the development of the lung, brain, and thyroid (1). In the lung TTF-1 positively regulates the expression of several lu...    Read more.
Read more TTF1 / NKX2.1 related blogs.