TNF p55 Products

TNF p55 Antibody
TNF p55 Antibody
Species: Hu, Pm
Applications: WB, ELISA
Host: Rabbit Polyclonal


Tumor Necrosis Factor (TNF) is a cytokine whose function is mediated through two distinct cell surface receptors (TNF Receptor I and TNF Receptor II) that are included in the TNF Receptor superfamily along with FAS antigen and CD40. TNF Receptors I and II are 55 and 75 kDa members, respectively, of a family of cell surface molecules including nerve growth factor receptor, Fas/Apo1, CD30, OX40, and 41BB, which are characterized by cysteine rich motifs in the extracellular domain. While TNF Receptor I and TNF Receptor II share 28% sequence homology in the extracellular domains, their intracellular domains lack sequence homology, suggesting that they differ in their internal signal transduction pathways. TNF Receptor I contains an approximately 80 amino acid death domain near its carboxy terminus capable of transmitting an apoptotic signal through its interaction with TRADD (TNF Receptor I associated death domain protein), and subsequent interactions with FADD. TNF Receptor I can also activate the transcription factor NFkB via TRAF2 (TNF Receptor associated factor 2). The cytoplasmic domain of TNF Receptor I can directly interact with Jak kinase, thereby activating the JAK/STAT signal transduction cascade. TNF Receptor I is expressed by virtually all nucleated mammalian cells, including hepatocytes, monocytes and neutrophils, cardiac muscle cells, endothelial cells, and CD34 + hematopoietic progenitors. Both TNF alpha and TNF beta bind to TNF Receptor I.


Product By Gene ID 7132
Alternate Names
  • Tumor necrosis factor receptor type I
  • p60
  • Tumor necrosis factor receptor 1
  • p55
  • CD120a antigen
  • TNFR-I
  • tumor necrosis factor-alpha receptor
  • TNF-RI
  • tumor necrosis factor receptor type 1
  • TNF-R1
  • tumor necrosis factor receptor superfamily member 1A
  • TNFR60
  • tumor necrosis factor receptor 1A isoform beta
  • TNF-R55
  • tumor necrosis factor binding protein 1
  • TNF-R-I
  • p55-R
  • TNF-R
  • TNFR55
  • CD120a
  • TNFARMGC19588
  • FPF
  • tumor necrosis factor receptor superfamily, member 1A

Research Areas for TNF p55

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Cytokine Research
Diabetes Research
Innate Immunity

Bioinformatics Tool for TNF p55

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