TATA binding protein TBP Products

Description

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that serves the same function as TBP and substitutes for TBP at some promoters that are not recognized by TFIID. It is essential for spermiogenesis and believed to be important in expression of developmentally regulated genes.

Bioinformatics

Entrez	6908 Human
Uniprot	NP_003185.1 Human
Product By Gene ID	6908
Alternate Names	GTF2D GTF2D1 HDL4 MGC126054 MGC126055 SCA17 TATA box binding protein TATA sequence-binding protein TATA-binding factor TATA-box binding protein N-terminal domain TATA-box factor TATA-box-binding protein TF2D TFIIDMGC117320 Transcription initiation factor TFIID TBP subunit

Research Areas for TATA binding protein TBP

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Transcription Factors and Regulators