TAS2R8 Products

RNAi
TAS2R8 RNAi
TAS2R8 RNAi
H00050836-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

TAS2R8 product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli. Useful Links; The Human Olfactory Data Exploratorium: HORDE; Olfactory Receptor Data Base: ORDB; Transmembrane Analysis: TM analysis

Bioinformatics

Entrez Human
Uniprot Human
Product By Gene ID 50836
Alternate Names
  • taste receptor, family B, member 5
  • taste receptor type 2 member 8
  • T2R8TRB5Taste receptor family B member 5
  • taste receptor, type 2, member 8

Research Areas for TAS2R8

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GPCR

Bioinformatics Tool for TAS2R8

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