SIGNR7/CD209g Products

Description

SIGNR7 (dendritic cell-specific ICAM-3 grabbing nonintegrin related gene 7), also known as CD209g, belongs to the family of C-type lectins that participate in innate immune responses by binding and clearing pathogens. SIGNR7 is one of several mouse proteins which are encoded by separate genes and exhibit structural and sequence homology to human DC-SIGN and DC-SIGNR (1 - 3). Mouse SIGNR7 is a type 2 membrane protein that consists of a 45 amino acid (aa) cytoplasmic domain, a 22 aa transmembrane segment, and a 188 aa extracellular domain with a juxtamembrane neck region and a single carbohydrate recognition domain (CRD). Within the CRD, mouse SIGNR7 shares 44% - 49% aa sequence identity with mouse SIGNR1, 2, 3, 4, and 5 and 81% with SIGNR8. It shares 44% - 54% aa sequence identity with the CRD of bovine SIGNR7, human DC-SIGN, human DC-SIGNR, and rat DC-SIGN. A SIGNR7 ortholog has been described in cow but not in human (4). SIGNR7 binds both fucose and mannose residues and shows a distinct binding preference for the 6’-sulfo-sialyl Lewis× carbohydrate (5). Its interaction with mannosylated BSA is disrupted at low pH (5).

Bioinformatics

Uniprot	CAL15171 Mouse
Alternate Names	CD209g SIGNR7