PTTG1/2/3 Products

Antibodies
PTTG1/2/3 Antibody
PTTG1/2/3 Antibody
NB100-92304
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PTTG1/2/3 Antibody
PTTG1/2/3 Antibody
NBP2-46709
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal

Description

The product of the oncogene PTTG, pituitary tumor transforming gene, is a human homolog of the anaphase-inhibitor vertebrate protein, securin. PTTG is a 22 kDa protein that contains a basic amino-terminal domain and an acidic carboxy-terminal domain, which acts as a transactivation domain when fused to a heterologous DNA binding domain. Human PTTG is overexpressed in Jurkat and is also detected in human thymus, testis, and placenta. PTTG is mainly expressed in the cytoplasm and is also partially localized to the nucleus. Vertebrate PTTG regulates the separin Esp1, which promotes chromatid separation, to overcome the cohesive forces that hold sister chromatids together. This regulatory function of PTTG suggests that defective regulation of cohesion may contribute to cancer by promoting chromosome instability. Although vertebrate PTTG shares cell-cycle functions with its yeast securin counterparts Pds1p and Cut2, none share sequence homology.

Bioinformatics

Entrez Human
Product By Gene ID 9232
Alternate Names
  • hPTTG
  • Pituitary tumor-transforming gene 1 protein
  • Esp1-associated protein
  • securin
  • ESP1-associated protein 1
  • TUTR1HPTTG
  • PTTGMGC138276
  • EAP1MGC126883
  • Tumor-transforming protein 1
  • pituitary tumor-transforming 1

Research Areas for PTTG1/2/3

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cell Cycle and Replication
Mitotic Regulators

PTMs for PTTG1/2/3

Learn more about PTMs related to PTTG1/2/3.

Phosphorylation
Methylation
Ubiquitination

Bioinformatics Tool for PTTG1/2/3

Discover related pathways, diseases and genes to PTTG1/2/3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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