PTPN6 Products

Antibodies
PTPN6 Antibody
PTPN6 Antibody
NBP1-83276
Species: Hu, Mu, Rt, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PTPN6 Antibody
PTPN6 Antibody
NBP1-32179
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
PTPN6 Antibody (NL213)
PTPN6 Antibody (NL213)
NBP2-29830
Species: Hu, Mu
Applications: WB, IP
Host: Rabbit Monoclonal
Antibody Pairs
PTPN6 Antibody Pair
PTPN6 Antibody Pair
H00005777-AP22
Species: Hu
Applications: S-ELISA
Lysates
PTPN6 Overexpression Lysate ( ...
PTPN6 Overexpression Lysate (Denat...
H00005777-T01
Species: Hu
Applications: WB
PTPN6 Overexpression Lysate ( ...
PTPN6 Overexpression Lysate (Native)
NBL1-14976
Applications: WB
PTPN6 Overexpression Lysate ( ...
PTPN6 Overexpression Lysate (Native)
NBP2-05773
Applications: WB
Proteins
PTPN6 Recombinant Protein Ant ...
PTPN6 Recombinant Protein Antigen
NBP1-83276PEP
Species: Hu
Applications: AC
PTPN6 Recombinant Protein
PTPN6 Recombinant Protein
NBC1-18382
Species: Hu
Applications: PAGE
RNAi
PTPN6 RNAi
PTPN6 RNAi
H00005777-R03
Species: Hu
Applications: RNAi, RNAi SP
PTPN6 RNAi
PTPN6 RNAi
H00005777-R02
Species: Hu
Applications: RNAi, RNAi SP
PTPN6 RNAi
PTPN6 RNAi
H00005777-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

SHP-1 (also called PTP1C, SH-PP1, HCP, SHP and PTPN6) is a protein tyrosine phosphatase (PTP) predominantly expressed in hematopoietic cells, and regulates multiple signaling pathways involved in hematopoietic cell growth, differentiation and activation (1). After cell stimulation, SHP-1 (as well as SHP-2), translocate from cytosol to plasma membrane and bind to the tyrosine-phosphorylated receptors through their SH2 domains, becoming activated in the process (2). SHP-1 has been involved in the negative regulation of various growth promoting receptors including receptor tyrosine kinase (c-Kit, CSF-1, EGF), cytokine receptors (IL-3, IFN-a/b) and other tyrosine based receptor CD22, B & T cell Ag receptor, Lck, Zap-70 and Vav (3-5).

Bioinformatics

Entrez Human
Mouse
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 5777
Alternate Names
  • PTP1C
  • Protein-tyrosine phosphatase 1C
  • tyrosine-protein phosphatase non-receptor type 6
  • Hematopoietic cell protein-tyrosine phosphatase
  • hematopoietic cell phosphatase
  • SHP1
  • SHP-1L
  • SHP-1
  • HPTP1C
  • HCPH
  • PTP-1CEC 3.1.3.48
  • HCPSH-PTP1
  • Protein-tyrosine phosphatase SHP-1
  • protein tyrosine phosphatase, non-receptor type 6

Research Areas for PTPN6

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Phospho-Specific
Protein Phosphatase

Bioinformatics Tool for PTPN6

Discover related pathways, diseases and genes to PTPN6. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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