Proteasome 19S S5A Products

Antibodies
Proteasome 19S S5A Antibody
Proteasome 19S S5A Antibody
NBP1-90821
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Proteasome 19S S5A Antibody
Proteasome 19S S5A Antibody
NBP2-19952
Species: Hu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Proteasome 19S S5A Antibody
Proteasome 19S S5A Antibody
NBP2-19951
Species: Hu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Antibody Pairs
Proteasome 19S S5A Antibody P ...
Proteasome 19S S5A Antibody Pair
H00005710-AP11
Species: Hu
Applications: S-ELISA
Lysates
Proteasome 19S S5A Overexpres ...
Proteasome 19S S5A Overexpression ...
H00005710-T01
Species: Hu
Applications: WB
Proteasome 19S S5A Overexpres ...
Proteasome 19S S5A Overexpression ...
NBL1-14902
Applications: WB
Proteins
Proteasome 19S S5A Recombinan ...
Proteasome 19S S5A Recombinant Pro...
H00005710-P01
Species: Hu
Applications: WB, ELISA, PA
Proteasome 19S S5A Partial Re ...
Proteasome 19S S5A Partial Recombi...
H00005710-Q01
Species: Hu
Applications: WB, ELISA, PA
Proteasome 19S S5A Recombinan ...
Proteasome 19S S5A Recombinant Pro...
NBP2-37888PEP
Species: Hu
Applications: AC

Description

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Product By Gene ID 5710
Alternate Names
  • S5a/antisecretory factor protein
  • 26S proteasome regulatory subunit S5A
  • RPN10 homolog
  • pUB-R5,26S proteasome regulatory subunit RPN10
  • Multiubiquitin chain-binding protein
  • multiubiquitin chain binding protein
  • Antisecretory factor 1
  • angiocidin
  • S5A
  • 26S proteasome non-ATPase regulatory subunit 4
  • Rpn10
  • AF-1,26S protease subunit S5a
  • AFMCB1
  • ASF
  • proteasome (prosome, macropain) 26S subunit, non-ATPase, 4

Research Areas for Proteasome 19S S5A

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Ubiquitin Proteasome Pathway

PTMs for Proteasome 19S S5A

Learn more about PTMs related to Proteasome 19S S5A.

Ubiquitination
Phosphorylation
Methylation
Biotinylation
Cleavage

Bioinformatics Tool for Proteasome 19S S5A

Discover related pathways, diseases and genes to Proteasome 19S S5A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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