Proteasome 19S S4 Products

Antibodies
Proteasome 19S S4 Antibody
Proteasome 19S S4 Antibody
NB120-3317
Species: Hu, Ye
Applications: WB, IP
Host: Rabbit Polyclonal

Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit and a 20S core alpha subunit interact specifically with the hepatitis B virus X protein, a protein critical to viral replication. This subunit also interacts with the adenovirus E1A protein and this interaction alters the activity of the proteasome. Finally, this subunit interacts with ataxin-7, suggesting a role for the proteasome in the development of spinocerebellar ataxia type 7, a progressive neurodegenerative disorder. (provided by RefSeq)

Bioinformatics

Entrez Human
Uniprot Human
Product By Gene ID 5700
Alternate Names
  • P26s4
  • proteasome 26S subunit, ATPase, 1,26S protease regulatory subunit 4
  • proteasome 26S ATPase subunit 1,26S proteasome AAA-ATPase subunit RPT2
  • Proteasome 26S subunit ATPase 1
  • P26S4
  • p56
  • S4MGC8541
  • MGC24583
  • proteasome (prosome, macropain) 26S subunit, ATPase, 1

Research Areas for Proteasome 19S S4

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Ubiquitin Proteasome Pathway

PTMs for Proteasome 19S S4

Learn more about PTMs related to Proteasome 19S S4.

Phosphorylation
Deacetylation
Acetylation

Bioinformatics Tool for Proteasome 19S S4

Discover related pathways, diseases and genes to Proteasome 19S S4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.