WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-PHost:
Hu, Mu, SyHa(-)Applications:
WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, CyTOF-readyHost:
Mu, Ha(-), Hu(-)Applications:
WB, ELISA, ICC/IF, IHC, IHC-Fr, IHC-P, IPHost:
p19ARF (mouse) and p14ARF (human) has become an important player in cell cycle regulation. In mice, tumor suppressor effects appear to be mediated by interactions between p19ARF and the p53 tumor suppressor protein. p19ARF counters uncontrolled proliferation and oncogenic signals in p53 dependent pathways. Proteins encoded by the INK4a/ARF locus also play a role in Abelson virus transformation. Both p16INK4a and p19ARF are expressed in many cells as they emerge from the apoptotic crisis that characterizes the transformation process. p19ARF is an important part in cellular defense against transforming signals from the Abl oncoprotein, providing direct evidence that the p19ARF-p53 regulatory loop plays an important role in lymphoma induction.
|Product By Gene ID
- cyclin-dependent kinase inhibitor 2A
- cell cycle negative regulator beta
- CDK4 inhibitor p16-INK4
- Multiple tumor suppressor 1
- Cyclin-dependent kinase 4 inhibitor A
- cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
Bioinformatics Tool for p19ARF
Discover related pathways, diseases and genes to p19ARF. Need help? Read the Bioinformatics Tool Guide
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Related p19ARF Blog Posts
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|You can't be without me - SNF5
The protein encoded by SNF5 is a component of the chromatin-remodeling protein complex responsible for relieving repressive chromatin structures by allowing the transcriptional machinery to access targets more effectively. SNF5 has been found to be a... Read more.