NGF R/TNFRSF16/p75NTR Products

Antibodies
NGF R/TNFRSF16/p75NTR Antibod ...
NGF R/TNFRSF16/p75NTR Antibody (74...
MAB367
Species: Hu, Ca
Applications: WB, IHC, ICC
Host: Mouse Monoclonal
Conjugate Catalog # Availability Size Price
NGF R/TNFRSF16/p75NTR Antibod ...
NGF R/TNFRSF16/p75NTR Antibody [Un...
AF1157
Species: Mu
Applications: WB, IHC
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
NGF R/TNFRSF16/p75NTR Antibod ...
NGF R/TNFRSF16/p75NTR Antibody [Un...
AF367
Species: Hu, Mu, Rt
Applications: WB
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Lysates
NGF R/TNFRSF16/p75NTR Overexp ...
NGF R/TNFRSF16/p75NTR Overexpressi...
NBL1-13635
Applications: WB
Proteins
NGF R/TNFRSF16/p75NTR Recombi ...
NGF R/TNFRSF16/p75NTR Recombinant ...
NBP1-85769PEP
Species: Hu
Applications: AC
Recombinant Human NGF R/TNFRS ...
Recombinant Human NGF R/TNFRSF16/p...
NBP2-52198
Species: Hu
Applications: PAGE
RNAi
NGF R/TNFRSF16/p75NTR RNAi
NGF R/TNFRSF16/p75NTR RNAi
H00004804-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

p75NTR was originally discovered as a low affinity nerve growth factor receptor. Later it was found that it was the receptor for all neurotrophins. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Recently, it has been revealed that p75NTR is not only acts as the receptor for neurotrophins but also the receptor for many other pathological ligands such as prions, rabies virus and amyloid beta. p75NTR also acts as a co-receptor for NOGO which mediates inhibitory signals of myelin associated protein. p75NTR is highly expressed in a number of non-neuronal and neuronal cells including motor neurons during development and also in damaged neurons. FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. DOMAIN: Death domain is responsible for interaction with RANBP9. PTM: N- and O-glycosylated. PTM: Phosphorylated on serine residues. SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 4 TNFR-Cys repeats.

Bioinformatics

Uniprot Human
Human
Human
Human
Rat
Product By Gene ID 4804
Alternate Names
  • CD271 antigen
  • NGF receptor
  • tumor necrosis factor receptor superfamily member 16
  • Gp80-LNGFR
  • member 16
  • CD271
  • TNFRSF16nerve growth factor receptor (TNFR superfamily, member 16)
  • p75 ICD
  • nerve growth factor receptor

Research Areas for NGF R/TNFRSF16/p75NTR

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Neuronal Cell Markers
Neuronal Stem Cell Markers
Neuroscience
Stem Cell Markers

PTMs for NGF R/TNFRSF16/p75NTR

Learn more about PTMs related to NGF R/TNFRSF16/p75NTR.

Phosphorylation
Cleavage
Methylation
Acetylation
Biotinylation
Glycosylation
Dephosphorylation

Bioinformatics Tool for NGF R/TNFRSF16/p75NTR

Discover related pathways, diseases and genes to NGF R/TNFRSF16/p75NTR. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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