MUC-1 Products

Antibodies
Antibody Pairs
MUC-1 Antibody Pair
MUC-1 Antibody Pair
H00004582-AP41
Species: Hu
Applications: S-ELISA
MUC-1 Antibody Pair
MUC-1 Antibody Pair
H00004582-AP42
Species: Hu
Applications: S-ELISA
Lysates
MUC-1 Overexpression Lysate ( ...
MUC-1 Overexpression Lysate (Native)
NBP2-08671
Applications: WB
MUC-1 Overexpression Lysate ( ...
MUC-1 Overexpression Lysate (Native)
NBL1-13391
Applications: WB
MUC-1 Overexpression Lysate ( ...
MUC-1 Overexpression Lysate (Native)
NBP2-08672
Applications: WB
Proteins
MUC-1 Partial Recombinant Pro ...
MUC-1 Partial Recombinant Protein
H00004582-Q01
Species: Hu
Applications: WB, ELISA, PA
MUC-1 Recombinant Protein Ant ...
MUC-1 Recombinant Protein Antigen
NBP1-85778PEP
Species: Hu
Applications: AC
MUC-1 Native Protein
MUC-1 Native Protein
P5239
Species: Bv
RNAi
MUC-1 RNAi
MUC-1 RNAi
H00004582-R07
Species: Hu
MUC-1 RNAi
MUC-1 RNAi
H00004582-R02
Species: Hu
MUC-1 RNAi
MUC-1 RNAi
H00004582-R04
Species: Hu

Description

Mucins are high molecular weight glycoproteins that provide a protective layer on epithelial surfaces and are involved in cell-cell interactions, signaling, and metastasis. MUC1 consists of an extracellular subunit and a membrane-associated subunit (1). The two moieties are produced from a single precursor polypeptide by an early proteolytic cleavage event but remain associated throughout intracellular processing and transport to the cell surface. It has been shown that MUC1 expression inhibits erbB1 (regulators of cell survival and growth) degradation and also E-cadherin (2). Isoform 7 of MUC1 behaves as a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Mouse
Product By Gene ID 4582
Alternate Names
  • KL-6
  • CD227 antigen
  • PEMT
  • Episialin
  • MUC-1
  • tumor associated epithelial mucin
  • H23AG
  • mucin-1
  • EMA
  • H23 antigen
  • Tumor-associated mucin
  • episialin
  • Tumor-associated epithelial membrane antigen
  • DF3 antigen
  • Polymorphic epithelial mucin
  • Peanut-reactive urinary mucin
  • Carcinoma-associated mucin
  • Breast carcinoma-associated antigen DF3
  • mucin 1, transmembrane
  • MUC1/ZD
  • CD227
  • PUMMUC-1/X
  • PEMMUC-1/SEC
  • MAM6
  • mucin 1, cell surface associated

Research Areas for MUC-1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cellular Markers
Extracellular Matrix

Bioinformatics Tool for MUC-1

Discover related pathways, diseases and genes to MUC-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related MUC-1 Blog Posts

Check out the latest blog posts on MUC-1.
Epithelial-Mesenchymal Transition (EMT) Markers
Epithelial-Mesenchymal Transition (EMT) is the trans-differentiation of stationary epithelial cells into motile mesenchymal cells. During EMT, epithelial cells lose their junctions and apical-basal polarity, reorganize their cytoskeleton, undergo a...    Read more.
Mucin 1 - a mucosal epithelial glycoprotein with importance in cancer diagnostics
Mucin 1 (Muc1) is a heavily glycosylated protein that coats mucosal epithelial cells of the lungs, intestines, and other organs. Muc1 is thought to protect cells by binding to pathogens and responding to infections. During trafficking to the plasma...    Read more.
Read more MUC-1 related blogs.