MHC Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. MHC class I antigens are heterodimers consisting of one alpha chain (44kDa) with beta 2 microglobulin (11.5 kDa). The antigen is expressed by all somatic cells at varying levels. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. Fibroblasts or neurons however only show a low level of antigen.
|Product By Gene ID
- MHC HLA-E alpha-2.1
- MHC HLA-E alpha-1
- lymphocyte antigen
- HLA class I histocompatibility antigen, E alpha chain
- MHC class I antigen E
- HLA class I histocompatibility antigen, alpha chain E
- major histocompatibility complex, class I, E
Bioinformatics Tool for MHC Class I H-2Kd
Discover related pathways, diseases and genes to MHC Class I H-2Kd. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.