MARK1/2/3/4 Products


MARK1 (MAP/microtubule affinity-regulating kinase 1) belongs to the MARK family of serine/threonine kinases. MARK family protein kinases phosphorylate microtubule-associated proteins and may play a role in cytoskeletal stability. MARK2 refers to MAP/microtubule affinity-regulating kinase 2 isoform a [Homo sapiens]. EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubulestability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1 called MARK2. MARK3 was originally identified as a marker that was induced by treatment with DNA damaging agents, and loss of MARK3 was found with carcinogenesis in the pancreas. MARK4 contains an N terminal serine/threonine kinase domain, a central ubiquitin associated domain, and a C terminal KA1 associated kinase domain. RT PCR analysis detects upregulated expression of the gene for MARK4 in nearly all clinical hepatocellular carcinoma cells.


Entrez Human
Product By Gene ID 4139
Alternate Names
  • EC 2.7.11
  • EC
  • KIAA1477serine/threonine-protein kinase MARK1
  • MARKMGC126513
  • MAP/microtubule affinity-regulating kinase 1MGC126512

Research Areas for MARK1/2/3/4

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Protein Kinase

PTMs for MARK1/2/3/4

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Bioinformatics Tool for MARK1/2/3/4

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