IFN-alpha H2/IFNA14 Products

Description

Interferons (IFN) are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties, classified based on their binding specificity to cell surface receptors (1). Human IFNA2 was originally cloned in the early ‘80s and now more than a dozen closely related IFN alpha subtypes have been identified in both the human and mouse genome, each sharing about 80% amino acid (aa) sequence homology (2-4). Structurally, type I IFNs belong to the class of five helical‑bundle cytokines, with the IFNA subtypes containing 2 conserved disulfide bonds (5). The extracellular domain (ECD) of mature human IFNA14, shares 58% aa sequence identity with mouse IFNA14. The type I IFNs bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 (alpha‑subunit) and IFNAR2 (beta-subunit) (6, 7). Individual IFNA subtypes are known to display unique efficacies to viral protection, and IFNA14 has been shown to be a strong inducer of IFN-stimulated genes and anti-viral protection (8). IFNA14 has been shown to be potent against HIV-1 by up‑regulating the transcription of two intrinsic restriction factors with well-established anti-HIV-1 activity, MX2 and tetherin (9).

Bioinformatics

Uniprot	P01570.3
Product By Gene ID	3448
Alternate Names	IFNA14 IFNalpha H2 IFN-alpha H2 IFN-alpha-14 IFN-alphaH interferon alpha-14 Interferon alpha-H Interferon lambda-2-H interferon, alpha 14 LeIF H LEIF2H MGC125756 MGC125757