HLA DQ/DQ3 Products


HLA-DQB1 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of analpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system bypresenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells(APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains 6 exons.Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes thetransmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the betachain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 differentmolecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. (provided by RefSeq)


Product By Gene ID 3117
Alternate Names
  • MHC HLA-DQ alpha
  • GSE
  • MHC class II surface glycoprotein
  • FLJ27328
  • MHC class II HLA-DQ-alpha-1
  • FLJ27088
  • MHC class II HLA-D alpha glycoprotein
  • DQ-A1
  • MHC class II antigen
  • CD
  • leukocyte antigen alpha chain
  • MHC class II DQA1
  • leucocyte antigen DQA1
  • DC-1 alpha chain
  • HLA class II histocompatibility antigen, DQ(W3) alpha chain
  • CELIAC1DQ alpha 1 chain
  • MGC149527
  • major histocompatibility complex, class II, DQ alpha 1

Research Areas for HLA DQ/DQ3

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Adaptive Immunity


Learn more about PTMs related to HLA DQ/DQ3.


Bioinformatics Tool for HLA DQ/DQ3

Discover related pathways, diseases and genes to HLA DQ/DQ3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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