HCST encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.
|Product By Gene ID
- Membrane protein DAP10
- kinase assoc protein
- phosphoinositide-3-kinase adaptor protein
- kinase assoc pro of ~10kDa
- KAP10DNAX-activation protein 10
- Transmembrane adapter protein KAP10
- hematopoietic cell signal transducer
Bioinformatics Tool for HCST
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