Granzyme B/H Products

Antibodies
Granzyme B/H Antibody
Granzyme B/H Antibody
NB100-91792
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal

Description

Granzyme A and granzyme B are serine proteases that mediate apoptotic signaling in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Both granzyme A and granzyme B are synthesized as inactive proenzymes, and they are stored within cytolytic granules and released by effector cells during degranulation. In activated CTLs, granzyme A and granzyme B are processed and activated by cathepsin C, and they then function to induce apoptosis by two distinct pathways. Granzyme B proteolytically cleaves and activates members of the caspase family of cysteine proteases, including caspase-3, caspase-6, caspase-7 and caspase-9. When cleaved, these caspases assemble into active holoenzymes that then mediate apoptosis through a defined proteolytic cascade involving nuclear lamins and PARP (poly ADP ribose polymerase). Granzyme A mediates the activation of apoptosis by inducing single-strand DNA breaks, membrane perturbation and nuclear condensations in an alternative pathway that is independent from caspase activation or the caspase proteolytic cascade.

Bioinformatics

Entrez Human
Mouse
Rat
Product By Gene ID 3002
Alternate Names
  • EC 3.4.21
  • Lymphocyte protease
  • Granzyme-2
  • Human lymphocyte protein
  • GRB
  • Cytotoxic T-lymphocyte proteinase 2
  • Fragmentin-2
  • Cathepsin G-like 1
  • granzyme-2
  • CSP-B
  • granzyme B
  • CGL-1
  • fragmentin-2
  • CCPI
  • CTLA1fragmentin 2
  • SECTCSPBcytotoxic serine protease B
  • HLPEC 3.4.21.79
  • CTSGL1T-cell serine protease 1-3E
  • CGL1CTLA-1
  • C11
  • granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)

Research Areas for Granzyme B/H

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Apoptosis
Cancer
Cell Biology
Diabetes Research
Immunology
Innate Immunity
Tumor Suppressors

Bioinformatics Tool for Granzyme B/H

Discover related pathways, diseases and genes to Granzyme B/H. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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