GC-SB2 Products

Antibodies
GC-SB2 Antibody
GC-SB2 Antibody
NBP1-19729
Species: Hu, Mu, Rt
Applications: IHC, IHC-P
Host: Rabbit Polyclonal

Description

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one 72 kDa alpha subunit and one 65 kDa beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity. The distribution of the beta-2 subunit seems to be much more restricted than the beta-1 subunit, with predominant expression in kidney and liver.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Product By Gene ID 2974
Alternate Names
  • GC-SB2
  • guanylate cyclase 1, soluble, beta 2

Pathways for GC-SB2

View related products by pathway and learn more about each of the pathways below.

Localization

Bioinformatics Tool for GC-SB2

Discover related pathways, diseases and genes to GC-SB2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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