Ephrin-B1 Products

Description

EphrinB proteins are thought to play key roles in cellular functions as diverse as neuronal migration and blood vessel development. EphrinB molecules expressed at the membrane surface bind to the EphB family receptors on target cells during cell-to cell contact. This interaction leads to cell signaling in the target cell but also generates a reverse signal in the cell expressing EphrinB on its surface. This reverse signaling event is thought to be critical for vessel maturation and neuronal development. Importantly, tyrosine phosphorylation of EphrinB is thought to be a critical component of this reverse signaling event. Recent work suggests that phosphorylation of a specific EphrinB residue (Tyr298) plays a key role in EphrinB signaling. (3, 5)

Bioinformatics

Uniprot	F7B9D9 Xenopus F7B9D9 Xenopus F7B9D9 Xenopus F7B9D9 Xenopus F7B9D9 Xenopus F7B9D9 Xenopus F7B9D9 Xenopus
Product By Gene ID	1947
Alternate Names	Cek5-L EFL3 EFL-3 EFNB1 ELK ligand ELK-L EphrinB1 Ephrin-B1 LERK-2 STRA-1

Research Areas for Ephrin-B1

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Neuroscience