ELKS Products

Description

Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. The protein is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13). Five transcript variants encoding different isoforms have been found for this gene.

Bioinformatics

Entrez	111173 Mouse 23085 Human
Uniprot	AAH05065.1 Human NP_829883.1 Human Q8IUD2 Human
Product By Gene ID	23085
Alternate Names	ELKS/RAB6-interacting/CAST family member 1 ELKSCAST2 ERC-1 FLJ31750 KIAA1081Cast2 MGC12974 RAB6 interacting protein 2 Rab6-interacting protein 2 RAB6IP2