Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratins assemble into filaments, forming heterodimers of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) (1,2). Keratin isoforms demonstrate tissue- and differentiation-specific profiles, which make them useful as biomarkers (1). Mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases (3-6). Moll, R. et al. (1982) Cell 31, 11-24. Chang, L. and Goldman, R.D. (2004) Nat. Rev. Mol. Cell Biol. 5, 601-613. Ramaekers, F.C. and Bosman, F.T. (2004) J. Pathol. 204, 351-354. Lane, E.B. and McLean, W.H. (2004) J. Pathol. 204, 355-366. Zatloukal, K. et al. (2004) J. Pathol. 204, 367-376. Owens, D.W. and Lane, E.B. (2004) J. Pathol. 204, 377-385.
|Product By Gene ID
- Cytokeratin-19,40-kDa keratin intermediate filament
- keratin, type I, 40-kd
- keratin, type I cytoskeletal 19
- cytokeratin 19
- keratin 19
Research Areas for Cytokeratin 19/10/12
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