Cytochrome P450 2C8/9/18/19 Products


The immunosuppressant cyclosporin A (CsA) forms a trimolecular complex with cyclophilin and calcineurins to inhibit calcineurin phosphatase activity. Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of the CsA and is encoded by a single unique gene conserved from yeast to humans. CyPA is known for its involvement in T cell differentiation and proliferation and is highly expressed in brain. CyPA is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1) via a direct interaction with the capsid domain of the viral Gag polyprotein and is crucial for efficient viral replication. Cyclophilin B (CyPB) is a member of the cyclophilin family with specific N- and C-terminal extensions. Unlike CyPA, CyPB has a signal sequence leading to its translocation in the endoplasmic reticulum. CyPB is secreted in biological fluids such as blood or milk and binds to a specific receptor present on the human lymphoblastic cell line Jurkat and on human peripheral blood lymphocytes.


Entrez Human
Product By Gene ID 1558
Alternate Names
  • xenobiotic monooxygenase
  • S-mephenytoin 4-hydroxylase
  • P450 form 1
  • Cytochrome P450 MP-20
  • microsomal monooxygenase
  • Cytochrome P450 MP-12
  • flavoprotein-linked monooxygenase
  • Cytochrome P450 IIC2
  • cytochrome P450 2C8
  • Cytochrome P450 form 1
  • MP-12/MP-20
  • cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8
  • EC
  • CPC8
  • cytochrome P450, family 2, subfamily C, polypeptide 8

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Lipid and Metabolism

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