cleaved Retinoblastoma 1 Products

Antibodies

Description

The retinoblastoma gene product (Rb) is a tumor suppressor protein and acts as cell cycle regulator (1). Recently, Rb has been shown to play a role in apoptosis. During apoptosis, Rb is subjected to cleavage by caspase-3 like protease. Caspase-3 cleaves Rb into 48 and 68kDa fragments (2-4). Cleavage of Rb would make it functionally inactive, causing release of E2F-1. The E2F-1 then may promote apoptosis (5).

Bioinformatics

Entrez Human
Mouse
Product By Gene ID 5925
Alternate Names
  • Rb
  • pp110
  • retinoblastoma-associated protein
  • pRb
  • retinoblastoma suspectibility protein
  • p105-Rb
  • OSRC
  • RB
  • osteosarcoma
  • retinoblastoma 1

Research Areas for cleaved Retinoblastoma 1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Transcription Factors and Regulators
Tumor Suppressors

Bioinformatics Tool for cleaved Retinoblastoma 1

Discover related pathways, diseases and genes to cleaved Retinoblastoma 1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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