WB, IHC, IHC-Fr, IHC-PHost:
Applications: IHC, IP, IF
Host: Mouse Monoclonal
The retinoblastoma gene product (Rb) is a tumor suppressor protein and acts as cell cycle regulator (1). Recently, Rb has been shown to play a role in apoptosis. During apoptosis, Rb is subjected to cleavage by caspase-3 like protease. Caspase-3 cleaves Rb into 48 and 68kDa fragments (2-4). Cleavage of Rb would make it functionally inactive, causing release of E2F-1. The E2F-1 then may promote apoptosis (5).
|Product By Gene ID
- retinoblastoma-associated protein
- retinoblastoma suspectibility protein
- retinoblastoma 1
Bioinformatics Tool for cleaved Retinoblastoma 1
Discover related pathways, diseases and genes to cleaved Retinoblastoma 1. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.