Applications: WB, Flow, ICC/IF, PAGE
Host: Mouse Monoclonal
The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kDa) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.
|Product By Gene ID
- Cadherin-associated protein
- catenin alpha-1
- catenin (cadherin-associated protein), alpha 1 (102kD)
- cadherin-associated protein
- Renal carcinoma antigen NY-REN-13
- Alpha E-catenin
- catenin (cadherin-associated protein), alpha 1, 102kDa
Bioinformatics Tool for Catenin alpha
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