Catenin alpha Products


The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kDa) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.


Entrez Human
Product By Gene ID 1495
Alternate Names
  • FLJ52416
  • Cadherin-associated protein
  • FLJ36832
  • catenin alpha-1
  • catenin (cadherin-associated protein), alpha 1 (102kD)
  • cadherin-associated protein
  • Renal carcinoma antigen NY-REN-13
  • alphaE-catenin
  • Alpha E-catenin
  • alpha-catenin
  • CAP102
  • alpha-E-catenin
  • catenin (cadherin-associated protein), alpha 1, 102kDa

Research Areas for Catenin alpha

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Cellular Markers
Core ESC-Like Genes
Cytoskeleton Markers
Stem Cell Markers

Bioinformatics Tool for Catenin alpha

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