Catenin alpha Products


Description

The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kDa) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.

Bioinformatics

Entrez Human
Mouse
Product By Gene ID 1495
Alternate Names
  • FLJ52416
  • Cadherin-associated protein
  • FLJ36832
  • catenin alpha-1
  • catenin (cadherin-associated protein), alpha 1 (102kD)
  • cadherin-associated protein
  • Renal carcinoma antigen NY-REN-13
  • alphaE-catenin
  • Alpha E-catenin
  • alpha-catenin
  • CAP102
  • alpha-E-catenin
  • catenin (cadherin-associated protein), alpha 1, 102kDa

Research Areas for Catenin alpha

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cellular Markers
Core ESC-Like Genes
Cytoskeleton Markers
Stem Cell Markers

Bioinformatics Tool for Catenin alpha

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