CALCRL Products

Antibodies
CALCRL Antibody
CALCRL Antibody
NLS6731
Species: Hu, Rt, Po, Bv, Ca, Eq, Gt, Ha, Mk, Pm, Rb, Xp, Fish, Guinea Pig, Mouse, Opossum, Zebrafish, Bat
Applications: IHC-P
Host: Rabbit Polyclonal
CALCRL Antibody
CALCRL Antibody
NLS6755
Species: Hu, Primate, Mouse, Rabbit, Monkey
Applications: IHC-P
Host: Rabbit Polyclonal
CALCRL Antibody
CALCRL Antibody
NBP1-85643
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
CALCRL Overexpression Lysate ...
CALCRL Overexpression Lysate (Dena...
H00010203-T02
Applications: WB
Proteins
CALCRL Recombinant Protein An ...
CALCRL Recombinant Protein Antigen
NBP1-85643PEP
Species: Hu
Applications: AC
CALCRL Partial Recombinant Pr ...
CALCRL Partial Recombinant Protein
H00010203-Q01
Species: Hu
Applications: WB, ELISA, PA
CALCRL Recombinant Protein
CALCRL Recombinant Protein
H00010203-G01
Species: Hu
Applications: Func
RNAi
CALCRL RNAi
CALCRL RNAi
H00010203-R01
Species: Hu

Description

Calcitonin receptor-like receptor (CRLR) is an Adrenomedullin Receptor that requires two additional proteins to function: a chaperone protein RAMP (receptor activity modifying protein) and the component protein RCP. The function of CRLR depends on its interaction with RAMP. When coexpressed with RAMP1, CRLR acts as a receptor for calcitonin gene-related peptide (CGRP). In contrast, when CRLR is coexpressed with either RAMP2 or RAMP3, it acts as a receptor for adrenomedullin. Activation of the receptor leads to an increase in intracellular cyclic AMP. CRLR mediates the vasorelaxation of arteries, suggesting a potential role for the receptor in reaction to injury, particularly in the treatment of pulmonary hypertension. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B-Cell/lung/testis, bone marrow, embryo, lung, and synovium libraries.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 10203
Alternate Names
  • calcitonin gene-related peptide type 1 receptor
  • CGRPRCRLRCalcitonin receptor-like receptor
  • CGRP type 1 receptor
  • calcitonin receptor-like

Research Areas for CALCRL

Find related products by research area and learn more about each of the different research areas below.

Cancer
GPCR

PTMs for CALCRL

Learn more about PTMs related to CALCRL.

Glycosylation
Phosphorylation
Amidation
Cleavage
Dephosphorylation
Ubiquitination

Bioinformatics Tool for CALCRL

Discover related pathways, diseases and genes to CALCRL. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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