ACAT Products

Antibodies
Lysates
ACAT Overexpression Lysate
ACAT Overexpression Lysate
NBP2-10868
Species: Hu
Applications: WB
Proteins
Recombinant Human ACAT GST (N ...
Recombinant Human ACAT GST (N-Term...
H00006646-Q01
Species: Hu
Applications: WB, ELISA, PA, AP
ACAT Recombinant Protein Anti ...
ACAT Recombinant Protein Antigen
NBP2-32052PEP
Species: Hu
Applications: AC

Description

Acely-CoA:cholestorl acyltransferase (ACAT) is an integral membrane enzyme that belongs to type-B carboxylesterase/lipase family. ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A (1). ACAT also function as a regulator of intracellular cholesterol homeostasis at single cell level. Two isoform of ACAT exists, ACAT1 and ACAT2, are expressed in liver and intestine. However, ACAT1 is only found in macrophages and SMCs (2). The accumulation of cholesteryl esters produced by ACAT in macrophages can lead to foam cell formation, an indication of early stage atherosclerosis. ACAT activity has been linked to Alzehimer's Diease, condition caused by excess amount of amyloid beta-peptide (Abeta). Atherogenic lipoproteins activate ACAT activity, where active ACAT can modulate the level of Abeta (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 6646
Alternate Names
  • ACACT1
  • ACACT
  • acyl-Coenzyme A: cholesterol acyltransferase
  • Cholesterol acyltransferase 1
  • RP11-215I23.2
  • Acyl-coenzyme A:cholesterol acyltransferase 1
  • EC 2.3.1.26
  • sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1
  • STATSOAT
  • ACATACAT1
  • ACAT-1
  • sterol O-acyltransferase 1

Pathways for ACAT

View related products by pathway and learn more about each of the pathways below.

Transport
Cell Adhesion
Sterol Transport
Acute-phase Response
Cell Cycle
Aging
Reverse Cholesterol Transport
Proteolysis
Cholesterol Transport

Research Areas for ACAT

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism

PTMs for ACAT

Learn more about PTMs related to ACAT.

Phosphorylation
Cleavage

Bioinformatics Tool for ACAT

Discover related pathways, diseases and genes to ACAT. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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