Blogs for August 2022

The NLRP3 Inflammasome: Macrophage Activator & Pathology Driver

Monday, August 22, 2022 - 14:03
R&D Systems Inflammasome activation pathway banner.

By Victoria Osinski, PhD

What is the NLRP3 Inflammasome?

With its critical role in innate immunity, the nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome is a sensor complex within cells that forms in response to endogenous danger signals, microbial motifs, and other environmental cues. The complex is made up of a sensor (NLRP3), an adaptor called the adaptor protein apoptosis-associated speck-like protein containing a caspase-recruitment domain...


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