14-3-3 zeta Antibody (2E11)

14-3-3 zeta is a 245 amino acid containing protein belonging to the 14-3-3 family that mediates signal transduction by binding to phosphoserine containing proteins. It is a highly conserved protein in both plants and mammals. The encoded protein interacts with IRS1 implicating a plausible role in regulating insulin sensitivity. There are several transcript variants, with seven known mammalian isoforms: alpha, beta, gamma, delta, epsilon, zeta and eta. 14-3-3 proteins function in broad regulation of proteins by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, and activation/repression of enzyme activity. The protein is highly abundant in brain.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC-P.

Showing Publications 1 - 3 of 3.

Publications using NBP2-27179	Applications	Species
Chauhan SS, Kaur J, Kumar M et al. Prediction of recurrence-free survival using a protein expression-based risk classifier for head and neck cancer Oncogenesis 2015-04-21 [PMID: 25893634] (IHC-P, Human)	IHC-P	Human
Kaur J, Matta A, Kak I et al. S100A7 overexpression is a predictive marker for high risk of malignant transformation in oral dysplasia. Int. J. Cancer. 2014-03-15 [PMID: 24122701] (IHC-P, Human) Details: Oral lesions, Fig 1, Table 2. 14-3-3 zeta was detected in both the cytoplasm and nucleus.	IHC-P	Human
Chaker S, Kashat L, Voisin S et al. Secretome proteins as candidate biomarkers for aggressive thyroid carcinomas. Proteomics. 2013-03-01 [PMID: 23319340] Details: The following antibodies cited were used for western blot and IHC:(p) IMG-6664 in thyroid carcinoma and benign thyroid cells. (See Figs 2 and 3).

Array NBP2-27179

• 14-3-3 zeta Antibodies
• 14-3-3 zeta Lysate
• 14-3-3 zeta Proteins and Enzyme