Peptide with sequence C-KGQTQNFKDAFSGRD corresponding to internal region according to NP_055146.1.
Predicted cross-reactivity based on sequence identity: Canine.
Western Blot 0.02 - 0.06 ug/ml
Peptide ELISA Detection limit 1:128000
WB: Approx. 50 kDa band observed in human spleen and human thymus lysates (calculated MW of 55.4 kDa band according to NP_055146.1). An anonymous customer has reported positive results on rat spinal cord.
SLC7A11 is a member of a heteromeric Na(+)-independent anionic amino acid transport system highly specific for cystine and glutamate. In this system, designated system Xc(-), the anionic form of cystine is transported in exchange for glutamate.[supplied by OMIM]
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xCT: The Membrane's Gatekeeper xCT is an obligate, electroneutral, membrane-bound anionic transporter responsible for regulating particular amino acid gradients via their transport through plasma membrane. The antiporter xCT superficially resembles an ion channel and preferentially... Read full blog post.
xCT: Friend or Foe? There are two opposing sides to the controversial cysteine/glutamate antiporter. On one hand, it can be viewed a guardian of the cell, protecting it from the damaging oxidative stress that can cause cell death and even cancer. But, conversely, it has... Read full blog post.