TNF-alpha (Tumor necrosis factor, alpha), a member of the TNF ligand superfamily, is among others, secreted by macrophages, activated monocytes, neutrophils, T-cells, B-cells and natural killer cells stimulated by bacterial lipopolysaccharides. TNF-alpha shows approximately 30% homology with TNF-beta. TNF-alpha plays an important role in the regulation of immune cells. TNF-alpha has many biological activities, including a cytotoxic effect to various tumor cells, causes inflammation, cellular proliferation and plays a critical role in mediating resistance to bacterial infections. Human and murine TNF-alpha show approximately 79% homology and human TNF-alpha is active on murine cells with a slightly reduced specific activity.
APC1 protein , Cachectin , DIF , TNF, monocyte-derived , TNF-a , TNF-alphacachectin , TNFATNF, macrophage-derived , TNFSF2TNF superfamily, member 2 , tumor necrosis factor (TNF superfamily, member 2) , tumor necrosis factor alpha , Tumor necrosis factor ligand superfamily member 2 , tumor necrosis factor , tumor necrosis factor-alpha