SREBP2 Products

SREBP2 Antibodies

NB100-74543
Western Blot: SREBP2 Antibody [NB100-74543] - Analysis of mouse liver (lane 1), rat liver (lane 2) and HepG2 (lane 3) cell lysates.Immunocytochemistry/Immunofluorescence: SREBP2 Antibody [NB100-74543] - Analysis of SREBP2 (green) showing staining in the cytoplasm of PC12 cells. (red) was stained with a flourescent red phalloidin and nuclei (blue) were stained with Hoechst or DAPI.
Species: Human, Mouse, Rat
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
MAB7119
Western Blot: SREBP2 Antibody (751512) [MAB7119] - Lysates of HeLa human cervical epithelial carcinoma cell line and Raji human Burkitt's lymphoma cell line. Gels were loaded with 30 ug of whole cell lysate (WCL) and 15 ug of nuclear extract (Nuc). PVDF membrane was probed with 2 ug/mL of Mouse Anti-Human SREBP2 Monoclonal Antibody (R&D Systems catalog # MAB7119) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (R&D Systems catalog # HAF018). Specific bands were detected for SREBP2 at approximately 125 kDa and 55-65 kDa (as indicated). This experiment was conducted under reducing conditions.Immunocytochemistry/Immunofluorescence: SREBP2 Antibody (751512) [MAB7119] - SREBP2 was detected in immersion fixed HepG2 human hepatocellular carcinoma cell line using Mouse Anti-Human SREBP2 Monoclonal Antibody (R&D Systems catalog # MAB7119) at 10 ug/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; R&D Systems catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to cell surfaces and cytoplasm.
Species: Human
Applications: WB, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
AF7119
Western Blot: SREBP2 Antibody [AF7119] - Lysates of HeLa human cervical epithelial carcinoma cell line and Raji human Burkitt's lymphoma cell line. Gels were loaded with 15 ug of nuclear extracts (Nuc). PVDF membrane was probed with 2 ug/mL of Goat Anti-Human SREBP2 Antigen Affinity-purified Polyclonal Antibody (R&D Systems catalog # AF7119) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (R&D Systems catalog # HAF017). Specific bands were detected for SREBP2 at approximately 125 kDa and 60-70 kDa (as indicated). This experiment was conducted under reducing conditions.Immunocytochemistry/Immunofluorescence: SREBP2 Antibody [AF7119] - SREBP2 was detected in immersion fixed HeLa human cervical epithelial carcinoma cell line using Goat Anti-Human SREBP2 Antigen Affinity-purified Polyclonal Antibody (R&D Systems catalog # AF7119) at 15 ug/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; R&D Systems catalog # NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm.
Species: Human
Applications: WB, ChIP, ICC/IF
Host: Goat Polyclonal

SREBP2 Kits

KA1378
Applications: Func, ICC/IF
KA1379
Applications: Func

SREBP2 Lysate

SREBP2 Protein

H00006721-H01
Applications: WB, B/N, ELISA
H00006721-Q01
Species: Human
Applications: WB, ELISA, PA
NBP1-71880PEP

SREBP2 RNAi

H00006721-R01
Species: Human

Description

SREBP2 encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Rat
Product By Gene ID 6721
Alternate Names
  • SREBP2
  • BHLHD2
  • Class D basic helix-loop-helix protein 2
  • bHLHd2sterol regulatory element-binding protein 2
  • SREBP2SREBP-2
  • Sterol regulatory element-binding transcription factor 2
  • sterol regulatory element binding transcription factor 2

Bioinformatics Tool for SREBP2

Discover related pathways, diseases and genes to SREBP2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 

Related SREBP2 Blog Posts

Check out the latest blog posts on SREBP2.
SREBP: Gatekeeper of Cholesterol Homeostasis
SREBP1 (sterol-regulatory-element-binding protein 2) is a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) transcription factor. It regulates sterol and cholesterol homeostasis by controlling enzymes involved in cholesterol synthesis and uptake, e.g. ...    Read more.
SREBPs: Global Regulator of Lipid Metabolism
Sterol regulatory element binding proteins (SREBPs) are indirectly required for cholesterol biosynthesis and for uptake and fatty acid biosynthesis. There are three known SREBP isoforms, SREBP1a, 1c and SREBP2; these have different roles in lipid synt...    Read more.
SREBP2: From Cholesterol Homeostasis to Cancer Invasion
Sterol-regulatory-element-binding protein 2 (SREBP2) is a transcription factor that regulates cholesterol homeostasis by controlling enzymes involved in cholesterol synthesis and uptake, e.g. HMG-CoA. Along with another transcription factor LXR, SREBP...    Read more.
ABCA1 Expression is Down-Regulated by SREBP microRNA
The ABCA1 (ATP-binding cassette transporter-A1) gene encodes a transmembrane protein, which plays a major role in phospholipid homeostasis by regulating cholesterol efflux from the cell. ABCA1 antibody studies have shown ABCA1 expression is up/down re...    Read more.
Read more SREBP2 related blogs.