SREBP2 Products

SREBP2 Antibodies

Western Blot: SREBP2 Antibody (1D2) [NBP1-54446] - Lane1: HEp-2 cells. Lane 2: MCF-7 cells. Lane 3: LNCaP cells. Lane 4: HT1080 cells. Lane5 ZR75-1 cells.Immunocytochemistry/Immunofluorescence: SREBP2 Antibody (1D2) [NBP1-54446] - SREBP2 (1D2) antibody was tested in HeLa cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).
Species: Human, Chicken
Applications: WB, ELISA, GS, ICC/IF, IP
Host: Mouse Monoclonal
Western Blot: SREBP2 Antibody [NB100-74543] - Analysis of 25 ug of mouse liver (lane 1), rat liver (lane 2) and HepG2 (lane 3) cell lysates.Immunocytochemistry/Immunofluorescence: SREBP2 Antibody [NB100-74543] - Analysis of SREBP2 (green) showing staining in the cytoplasm of HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a SREBP2 polyclonal antibody in 3% BSA-PBS at a dilution of 1:100 and incubated overnight at 4C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight-conjugated secondary antibody in PBS at room temperature in the dark. F-actin (red) was stained with a flourescent red phalloidin and nuclei (blue) were stained with Hoechst or DAPI.
Species: Human, Mouse, Rat
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line and Raji human Burkitt's lymphoma cell line. Gels were loaded with 30 µg of whole cell lysate (WCL) and 15 µg of nuclear extract (Nuc). PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human SREBP2 Monoclonal Antibody (Catalog # MAB7119) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # <A class=NoLineLink href=SREBP2 was detected in immersion fixed HepG2 human hepatocellular carcinoma cell line using Mouse Anti-Human SREBP2 Monoclonal Antibody (Catalog # MAB7119) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # <a class=
Species: Human
Applications: WB, IHC, ICC
Host: Mouse Monoclonal


Applications: Func, ICC/IF
Applications: Func

SREBP2 Lysate

SREBP2 Proteins

Species: Human
Applications: WB, ELISA, PA
Species: Human
Applications: B/N, Ctrl


Species: Human


SREBP2 encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.


Entrez Human
Uniprot Human
Product By Gene ID 6721
Alternate Names
  • SREBP2
  • BHLHD2
  • Class D basic helix-loop-helix protein 2
  • bHLHd2sterol regulatory element-binding protein 2
  • Sterol regulatory element-binding transcription factor 2
  • sterol regulatory element binding transcription factor 2

Bioinformatics Tool for SREBP2

Discover related pathways, diseases and genes to SREBP2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Related SREBP2 Blog Posts

Check out the latest blog posts on SREBP2.
SREBP2 - regulating cholesterol homeostasis and lipid metabolism
Sterol regulatory element-binding proteins (SREBP) are important transcription factors regulating the synthesis and uptake of lipids including cholesterol. This essential role in lipid metabolism makes investigations into the functions SREBPs im...    Read more.
SREBP: Gatekeeper of Cholesterol Homeostasis
SREBP1 (sterol-regulatory-element-binding protein 2) is a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) transcription factor. It regulates sterol and cholesterol homeostasis by controlling enzymes involved in cholesterol synthesis and uptake, e.g....    Read more.
SREBPs: Global Regulator of Lipid Metabolism
Sterol regulatory element binding proteins (SREBPs) are indirectly required for cholesterol biosynthesis and for uptake and fatty acid biosynthesis. There are three known SREBP isoforms, SREBP1a, 1c and SREBP2; these have different roles in lipid synt...    Read more.
SREBP2: From Cholesterol Homeostasis to Cancer Invasion
Sterol-regulatory-element-binding protein 2 (SREBP2) is a transcription factor that regulates cholesterol homeostasis by controlling enzymes involved in cholesterol synthesis and uptake, e.g. HMG-CoA. Along with another transcription factor LXR, SREBP...    Read more.
ABCA1 Expression is Down-Regulated by SREBP microRNA
The ABCA1 (ATP-binding cassette transporter-A1) gene encodes a transmembrane protein, which plays a major role in phospholipid homeostasis by regulating cholesterol efflux from the cell. ABCA1 antibody studies have shown ABCA1 expression is up/down re...    Read more.
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