Mitochondrial Fusion Proteins

Mitochondria are remarkably dynamic organelles that undergo continual cycles of fusion and fission which play important roles in the regulation of apoptosis. The equilibrium of these two opposing processes determines not only the overall morphology of mitochondria in cells, but also has important consequences for mitochondrial function. Mitochondrial fusion contributes to the shape and distribution of mitochondria in the cytoplasm. Three GTPases are crucial for mitochondrial fusion. The mitofusins (Mfn1 and Mfn2) are transmembrane GTPases embedded in the outer membrane of mitochondria, and OPA1 is a dynamin-related protein localized to the intermembrane space. Mitochondrial fission requires the function of Drp1, a dynamin-related protein that is recruited to the mitochondrial surface to promote fission.   All Mitochondrial Fusion Antibodies, Lysates, Proteins, and RNAi

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