Circadian Rhythm

Biological timepieces called circadian clocks are responsible for the regulation of hormonal rhythms, sleep cycles, body temperature, blood pressure,  and other behaviors. The superchiasmatic nucleus (SCN), which is located in the brain, was the first mammalian circadian clock to be discovered. CLOCK, a member of the basic-helix-loop-helix-PAS (bHLH-PAS) family of transcription factors, has also been identified as having circadian function. Mutations within the CLOCK gene have been shown to increase the length of the endogenous period and to cause a loss of rhythmicity of circadian oscillations. CLOCK contains a DNA-binding domain, a protein dimerization domain and a glutamine-rich C-terminal region, which indicates transactivation capabilities. It has been speculated that CLOCK may regulate circadian rhythmicity in combination with other proteins such as PER1, PER2 and BMAL1.  Another family of proteins implicated in the circadian rhythm are Cryptochromes.  Cryptochromes are blue, ultraviolet-A photoreceptor pigment proteins that are involved circadian rhythm regulation in plants and animals. In mammals, Cry 1 and 2 expression oscillates with respect to the daily light-dark cycle in the suprachiasmatic nucleus of the hypothalamus. These proteins localize to the cell nucleus, interact with each of the PER proteins, and assist in the translocation of PER from the cytoplasm to nucleus.

All Circadian Rhythm Antibodies, Lysates, Proteins, and RNAi

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