Alzheimer's Disease (AD) is the most common form of dementia that affects 5.3 million Americans. AD causes the damage and destruction of nerves in the brain. Hallmark abnormalities include deposits of beta-amyloid (plaques) and twisted strands of tau (tangles). Beta-amyloid peptide, a protein derived from amyloid precursor protein (APP)
, aggregates into a beta-pleated sheet configuration which is neurotoxic and forms the core of neuritic plaques. These abnormalities disrupt cellular communication, cause damage via oxidative metabolism, initiate abnormal accumulation of cytoskeletal proteins and result in cell death. Genes identified as causing susceptibility to Alzheimer's disease do not singly cause the disease state, but when combined with other epigenetic and environmental factors can lead to the condition.
All Alzheimer's Disease Antibodies, Lysates, Proteins, and RNAi
Research Cloud — Top terms most co-occuring with "Alzheimer's Disease" in scientific publications. Click to explore.