Receptors on the surface of macrophages, including Toll-Like Receptors (TLRs), sense pathogen components and tell the macrophage to produce and secrete cytokines.  These cytokines then recruit other cells to defend the infected tissue. All TLRs trigger an intercellular signaling pathway that leads to the translocation of the transcription factor nuclear factor kappa B (NFkB) from the cytoplasm to the nucleus. Once present in the nucleus, NFkB directs the transcription of genes for inflammatory cytokines.

Browse our Toll-Like Receptor antibodies including:

• TLR2 Antibodies
• TLR4 Antibodies
• TLR5 Antibodies
• TLR7 Antibodies
• TLR9 Antibodies

Research Cloud — Top terms most co-occuring with "TOLL-LIKE RECEPTOR SIGNALING PATHWAY" in scientific publications. Click to explore.