HIF Target Genes

Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in the available oxygen in the cellular environment (specifically hypoxia). This transcriptional complex plays a role in mammalian oxygen homeostasis and is comprised of an alpha-beta heterodimer; HIF-1 beta being a constitute nuclear protein that dimerizes with oxygen-regulated HIF-1 alpha subunits.

All Hypoxia Inducible Factor Target Gene Antibodies, Lysates, Proteins and RNAi

Research Cloud — Top terms most co-occuring with "Response to hypoxia" in scientific publications. Click to explore.