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Non-homologous end-joining (NHEJ) is one mechanism used in the repair of DNA double-strand breaks (DSB). NHEJ is referred to as 'non-homologous' because the broken ends are directly ligated without the need for a homologous template, as is necessary for homologous recombination. NHEJ is evolutionarily conserved throughout all kingdoms of life and is the predominant DSB repair pathway in many organisms. This mechanism typically utilizes short homologous DNA sequences (microhomologies) to guide repair. Microhomologies in the single-stranded overhangs that are often present on the ends of DSB are used to promote restorative repair. When these overhangs are compatible, NHEJ almost always repairs the break accurately with no sequence loss. Imprecise repair leading to the loss of nucleotides can also occur, but is much less common. The NHEJ pathway is also responsible for fusing the ends of chromosomes that have undergone telomere failure.

 

All Non-Homologous end-joining Antibodies, Lysates, Proteins, and RNAi