Checkpoint signaling

Checkpoint signaling regulates DNA damage and replication, cell cycle progression and apoptosis. Cell cycle checkpoints are signal transduction pathways that link the pace of phase transitions to the timely and accurate completion of prior periods. Although intranuclear checkpoint signaling functions are essential, extranuclear events such as growth factor availability are equally important. Checkpoint proteins are potential targets for cancer therapies as they play an essential role in oncogenesis. ATM and ATR are two important and well studied checkpoint mediators.   All Checkpoint Signaling Antibodies, Lysates, Proteins, and RNAi

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