mTOR Pathway

The mTOR pathway is regulated by a wide variety of cellular signals, including mitogenic growth factors, hormones such as Insulin, nutrients (amino acids, glucose), cellular energy levels, and stress conditions such as hypoxia. Through extensive research, it has become clear that the mTOR (Mammalian Target of Rapamycin) kinase is the central modulator of proliferative signal transduction. mTOR is a 289- kDa serine/threonine protein kinase belongs to the PIKK (Phosphatidylinositol 3-Kinase-related Kinase) family. Activation of mTOR induces phosphorylation of downstream targets, resulting multiple events as increased transcription and protein synthesis, which leads to cell growth and proliferation, as well as mitochondrial metabolism.  In addition, activation or mTOR pathway also promotes cell survival and angiogenesis, and involves in suppression of autophagy induction.  Aberrant mTOR signaling is involved in many disease states including cancer, cardiovascular disease and metabolic disorders. 

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All mTOR Pathway Antibodies, Lysates, Proteins, and RNAi

Research Cloud — Top terms most co-occuring with "mTOR" in scientific publications. Click to explore.