Nuclear Receptor SHP Proteins

We offer Nuclear Receptor SHP Peptides and Nuclear Receptor SHP Proteins for use in common research applications: ELISA, Western Blot. Each Nuclear Receptor SHP Peptide and Nuclear Receptor SHP Protein is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. Our Nuclear Receptor SHP Peptides and Nuclear Receptor SHP Proteins can be used in a variety of model species: Human. Use the list below to choose the Nuclear Receptor SHP Peptide and Nuclear Receptor SHP Protein which is most appropriate for your research; you can click on each one to view full technical details, images, references, reviews and related products. Choose from our Nuclear Receptor SHP Peptides and Proteins.

Gene ID: 8431

SHP (short heterodimer partner) is a bile acid-dependent orphan NR0 Knirps-Like receptor with dimerization and ligand-binding domains but not the conventional DNA-binding domain. SHP has been shown to inhibit the transcriptional activity of other nuclear receptors, including thyroid hormone receptor, constitutive androstane receptor, and retinoic acid receptors. SHP affects hepatic cholesterol catabolism based on a two-step mechanism dependent on both coactivator competition and direct transcriptional repression by mediating the repression of CYP7A1, the rate-limiting enzyme for bile acid synthesis. Mutations in the SHP gene contribute to increased body weight, indicating a possible role of SHP in the development of early-onset diabetes (maturity-onset diabetes of the young, MODY). Loss of SHP in mice caused abnormal accumulation and increased synthesis of bile acids due to derepression of rate-limiting CYP7A1 and CYP8B1 hydroxylase enzymes in the biosynthetic pathway. SHP expression has been documented in human liver, adrenal, spleen, and pancreas. ESTs have been isolated from cancerous human kidney, lung, and stomach, as well as normal human heart, kidney, liver, and liver/spleen. Caution: The nuclear receptor SHP should not be confused with the tyrosine phosphatases SHP-1 and SHP-2.