IRS2 Antibodies

We offer IRS2 Antibodies for use in common research applications: ELISA, Immunocytochemistry, Immunohistochemistry, Immunohistochemistry-Paraffin, immunoprecipitation, Western Blot. Each IRS2 Antibody is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. Our IRS2 Antibodies can be used in a variety of model species: Human, Mouse, Rat. Use the list below to choose the IRS2 Antibody which is most appropriate for your research; you can click on each one to view full technical details, images, references, reviews and related products. Choose from our IRS2 polyclonal antibodies and browse our IRS2 monoclonal antibody catalog.

8660

Showing 1 through 6 of our 6 IRS2 Antibody products.
Name Catalog# Reactivity Applications Images Pubs Reviews  
IRS2 Antibody (EP903Y)
Rabbit Monoclonal
NB110-57138 Hu, Mu(-), Rt(-) ICC, IHC, IP, WB (2)
$295.00




IRS2 Antibody
Rabbit Polyclonal
NB100-68242 Hu IP, WB (1)
$325.00




IRS2 Antibody
Rabbit Polyclonal
NB100-68243 Hu IP, WB (1)
$325.00




IRS2 Antibody
Rabbit Polyclonal
NB100-68244 Hu IP (1)
$325.00




IRS2 Antibody
Rabbit Polyclonal
NBP1-03350 Hu IHC-P (1)
$375.00




IRS2 Antibody
Rabbit Polyclonal
NB600-1373 Hu, Mu, Rt ELISA, IP, WB
$295.00




Insulin receptor substrates (IRS), the major intracellular substrates of the insulin receptor (IR), are adaptor proteins that transduce signals from the IR to downstream effectors that are important for the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosphorylated on multiple tyrosine residues. Once phosphorylated, IRS proteins bind and activate Grb-2, SHP2 and the PI3-K p85 subunit (2-3). Sequences of IRS-2 and IRS-1 reveal a highly conserved amino terminus containing a pleckstrin-homology domain and a phosphotyrosine-binding domain, and a poorly conserved carboxy terminus containing several tyrosine phosphorylation motifs. IRS-2 is expressed in many cells, including tissues from IRS-1-/- mice, and may be essential for signaling by several receptor systems such as insulin and cytokine (1).

IRS2 Synonyms:
anti-insulin receptor substrate 2 antibody, anti-IRS 2 antibody, anti-IRS-2 antibody, anti-IRS2 antibody
 

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