IRS2 Antibodies

We offer IRS2 Antibodies for use in common research applications: ELISA, Immunocytochemistry, Immunohistochemistry, Immunohistochemistry-Paraffin, immunoprecipitation, Western Blot. Each IRS2 Antibody is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. Our IRS2 Antibodies can be used in a variety of model species: Human, Mouse, Rat. Use the list below to choose the IRS2 Antibody which is most appropriate for your research; you can click on each one to view full technical details, images, references, reviews and related products. Choose from our IRS2 polyclonal antibodies and browse our IRS2 monoclonal antibody catalog.

Gene ID: 8660

Insulin receptor substrates (IRS), the major intracellular substrates of the insulin receptor (IR), are adaptor proteins that transduce signals from the IR to downstream effectors that are important for the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosphorylated on multiple tyrosine residues. Once phosphorylated, IRS proteins bind and activate Grb-2, SHP2 and the PI3-K p85 subunit (2-3). Sequences of IRS-2 and IRS-1 reveal a highly conserved amino terminus containing a pleckstrin-homology domain and a phosphotyrosine-binding domain, and a poorly conserved carboxy terminus containing several tyrosine phosphorylation motifs. IRS-2 is expressed in many cells, including tissues from IRS-1-/- mice, and may be essential for signaling by several receptor systems such as insulin and cytokine (1).