p62/SQSTM1 Antibody (NBP1-49956)

p62/SQSTM1 Antibody (NBP1-49956) (0.1 ml)

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	Catalog Number	NBP1-49956
	Size(s)	0.1 ml	Price:
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anti-P62 antibody, anti-OSIL antibody, anti-ORCA antibody, anti-EBIAP antibody, anti-sequestosome-1 antibody, anti-Ubiquitin-binding protein p62 antibody, anti-phosphotyrosine independent ligand for the Lck SH2 domain p62 antibody, anti-Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa antibody, anti-EBI3-associated protein p60 antibody, anti-p62B antibody, anti-ZIP3 antibody, anti-p62 antibody, anti-oxidative stress induced like antibody, anti-Paget disease of bone 3 antibody, anti-A170 antibody, anti-p60PDB3 antibody, anti-EBI3-associated protein of 60 kDa antibody, anti-sequestosome 1 antibody

p62/SQSTM1 Antibody Summary:

Species:	Hu, Mu	Gene:	SQSTM1
Applications:	WB, IP	Purity:	Affinity purified
Clonality:	Polyclonal	Host:	Rabbit
Publications:

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Lysates	Peptides and Proteins
Primary Antibodies	RNAi
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p62/SQSTM1 Antibody Details:

Immunogen:	The immunogen for this product maps to a region between residue 425 and 440 of human Sequestosome-1 using the numbering given in entry NP_003891.1 (GeneID 8878).

Species Reactivity:

Human, Mouse

Applications:

Uses:	This antibody works in Western Blot 1:2000 - 1:10000, 2 - 5 mcg/mg.
Dilutions:	Western Blot 1:2000 - 1:10000, Immunoprecipitation 2 - 5 mcg/mg
Unit Size:	0.1 ml
Concentration:	0.2 mg/ml

Packaging:

Storage:	Store at 4°C. Do not freeze.
Buffer:	Tris-buffered Saline containing 0.1% BSA.
Preservative:	0.09% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: SQSTM1

Related Genes:

Background:

SQSTM1/p62 is an adapter protein which binds ubiquitin and regulates signaling cascades through ubiquitination. It may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. More recently, a role for SQSTM1/p62 in macroautophagic removal of intracellular protein aggregates has also been proposed. Studies involving the cellular depletion of SQSTM1/p62 have indicated a need for its association with LC3 and the aggregate proteins in order to facilitate correct formation of the autophagosome. Defects in SQSTM1/p62 are a cause of Paget disease of bone which is a metabolic bone disease affecting the axial skeleton and characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts.

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p62/SQSTM1 Antibody Images (1)

Western Blot: p62/SQSTM1 Antibody [NBP1-49956] - Detection of Human and Mouse Sequestosome-1 by Western Blot (h&m) and Immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 mcg), and mouse NIH3T3 (M; 50 mcg) cells. Antibodies: Affinity purified rabbit anti-Sequestosome-1 antibody used for WB at 0.04 mcg/ml (A) and 0.4 mcg/ml (B) and used for IP at 3 mcg/mg lysate. Sequestosome-1 was also immunoprecipitated by rabbit anti-Sequestosome-1 antibodies which recognize upstream epitopes. For blotting immunoprecipitated Sequestosome-1 was used. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 3 seconds (B).