p62/SQSTM1 Antibody (NBP1-42822)

p62/SQSTM1 Antibody (NBP1-42822) (0.025 ml)

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	Catalog Number	NBP1-42822
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anti-P62 antibody, anti-OSIL antibody, anti-ORCA antibody, anti-EBIAP antibody, anti-sequestosome-1 antibody, anti-Ubiquitin-binding protein p62 antibody, anti-phosphotyrosine independent ligand for the Lck SH2 domain p62 antibody, anti-Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa antibody, anti-EBI3-associated protein p60 antibody, anti-p62B antibody, anti-ZIP3 antibody, anti-p62 antibody, anti-oxidative stress induced like antibody, anti-Paget disease of bone 3 antibody, anti-A170 antibody, anti-p60PDB3 antibody, anti-EBI3-associated protein of 60 kDa antibody, anti-sequestosome 1 antibody

p62/SQSTM1 Antibody Summary:

Species:	Hu, Mu, Rt	Gene:	SQSTM1
Applications:	WB, ICC, IF	Purity:	Affinity purified
Clonality:	Polyclonal	Host:	Rabbit
Publications:	NBP1-42822 has at least 1 Background Reference

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Lysates	Peptides and Proteins
Primary Antibodies	RNAi
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p62/SQSTM1 Antibody Details:

Immunogen:	A synthetic peptide made to an internal region of the human p62 protein (within residues 400-450). [Swiss-Prot Q13501]
Localization:	Cytoplasm. Lat endosome. Nucleus.

Species Reactivity:

Human, mouse and rat.

Applications:

Uses:	This SQSTM1/p62 antibody is useful for immunocytochemistry and Western blot, where a band is seen ~50 kDa.
Dilutions:	Immunocytochemistry 1:50, Immunofluorescence, Western Blot 1:2000
Unit Size:	0.025 ml (also available: 0.1 ml)
Concentration:	1.0 mg/ml
Conjugated Antibodies:	5 Conjugated Antibodies

Packaging:

Storage:	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Buffer:	PBS, 30% glycerol
Preservative:	0.1% Sodium Azide
Limitations:	This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.

Gene Symbol: SQSTM1

Entrez:	8878 (Human)
Uniprot:	Q13501 (Human)

Related Genes:

Background:

SQSTM1/p62 is an adapter protein which binds ubiquitin and regulates signaling cascades through ubiquitination. It may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. More recently, a role for SQSTM1/p62 in macroautophagic removal of intracellular protein aggregates has also been proposed. Studies involving the cellular depletion of SQSTM1/p62 have indicated a need for its association with LC3 and the aggregate proteins in order to facilitate correct formation of the autophagosome.

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p62/SQSTM1 Antibody Images (2)

	Western Blot: SQSTM1 Antibody [NBP1-42822] - Western blot analysis of SQSTM1 in HeLa whole cell extracts using NBP1-42822.

	Immunocytochemistry: SQSTM1 Antibody [NBP1-42822] - SQSTM1 staining in of Hela cells detected with a Dylight 488 labeled secondary antibody (Green) with Hoechst 33258 nuclear counterstain (Blue).