p62/SQSTM1 Antibody (NBP1-03489)

p62/SQSTM1 Antibody

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p62/SQSTM1 Antibody Summary:
Species:Hu
Applications:IHC-Fr, IHC-P, WB
Clonality:Polyclonal
Gene:SQSTM1
Purity:IgG purified
Host:Rabbit
Specificity:sequestosome-1.
Publications:Antibody has at least 10 Background References.
Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
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p62/SQSTM1 Antibody Details:
Isotype:IgG
Immunogen:A synthetic peptide as a part of sequestosome-1 (ubiquitin-binding protein p62, p60, EBIAP) conjugated to immunogenic carrier protein has been used as the immunogen.
Localization:subcellular location: cytoplasm. late endosome. nucleus. note=sarcomere. in cardiac muscles localizes to the sarcomeric band. localizes to late endosomes. may also localize to the nucleus.
Species Reactivity:

Human.

Applications:
Uses:Immunohistochemistry-Paraffin/Frozen and Western Blot
Dilutions:Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot 10-50 ug/ml
Unit Size:0.5 mg
Concentration:lyoph
Positive Controls:1 Positive Controls
Notes:
Reconstitute in 0.5 ml of sterile water. Centrifuge to remove any insoluble material. When reconstituting, glycerol (1:1) may be added for an additional stability.
Packaging:
Storage:Store at 4 °C short term. Aliquot and store at -20 °C long term. Avoid freeze-thaw cycles.
Buffer:Lyophilized in PBS
Preservative:No Preservative
Limitations:This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
Gene Symbol: SQSTM1
Entrez8878 (Human)
Swiss ProtQ13501 (Human)
 
Background:

Adapter protein which binds ubiquitin and may regulate the activation of nfkb1 by tnf-alpha, nerve growth factor (ngf) and interleukin-1. may play a role in titin/ttn downstream signaling in muscle cells. may regulate signaling cascades through ubiquitination. may be involved in cell differentiation, apoptosis, immune response and regulation of k(+) channels.

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Publications (10)

p62/SQSTM1 Antibody Background References:

  1. Olsen J.V, et al. Cell 127:635-648(2006).
  2. Nousiainen M, et al. Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).

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Jump to: Positive Controls, Lysates, Peptides and Proteins, Primary Antibodies, RNAi, Secondary Antibodies

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p62/SQSTM1 in Context


Research Areas related to p62/SQSTM1 (2):
Novus Explorer for p62/SQSTM1 gene

Try our bioinformatic tool that shows the relationships between SQSTM1 and other genes, diseases, pathways and post-translational modifications.