NFKB Signaling Pathway

Nuclear factor kappa beta (NFkB) is a nearly ubiquitous pathway responsible for mediating DNA transcription, and therefore cell function. The pathway is activated by a variety of stimuli including cellular stress, cytokines, free radicals, UV radiation, oxidized LDL, and bacterial/viral infection.

Activated NFkB is translocated to the nucleus where it binds to specific sequences of DNA called response elements. This DNA/NFkB complex then recruits RNA polymerase and other coactivators, which transcribe downstream DNA into mRNA, for protein synthesis.

NFKB Pathway

Explore Your Pathways With Novus Explorer! This free bioinformatics tool is designed to facilitate scientific exploration of related genes, diseases and pathways based on co-citations.

Novus Biologicals offers a number of top quality antibodies for the NFkB signaling pathway proteins, with some of our most popular included in the table below. Please feel follow the protein name links for additional products for each protein, or the catalog number links for more detail on the individual antibodies.

NFkB Signaling Pathway Antibodies

Name Catalog # Species Applications
c-Rel NBP1-62000 Hu WB, ELISA, IHC-P
FADD NB100-92032 Hu, Ms WB, IHC-P
IKK alpha NB100-91824 Hu, Mu, Rt WB, IHC-P
IKK beta NB100-56509 Hu, Ms WB, FACS, IHC-P, IP
IKK gamma NBP1-84681 Hu WB, ICC/IF, IHC-P
IL1 alpha NB100-2184 Hu WB, ELISA
IL1 beta NB600-633 Hu, Ca, Mk WB, ELISA, IHC, IP
IL1 Receptor NB110-85471 Ms WB, IHC-P
IRAK NBP1-61700 Hu WB, ELISA, ICC/IF, IHC-P
MyD88 NBP1-19785 Hu, Mu, Rt WB, IHC-P
NFkB p105/p50 NBP1-77395 Hu, Ms WB, ICC/IF, IHC-P
NFkB p65 NBP1-96139 Hu, Ms, Mk WB, ICC/IF, IHC-P
pan PKC NB600-201 Hu, Mu, Rt WB, ELISA, ICC/IF, IHC-Fr, IHC-P, IP, RIA
TCR-alpha NBP1-45883 Hu, Mu, Rt WB, IHC-Fr, IHC-P, IP
TRAF6 NBP1-33357 Hu WB
RelB NB110-57461 Hu WB, ICC/IF, IHC-P, IP

 

NFkB Signaling Pathway References

  1. Shapshak P. Bioinformation and molecule of the month: Multiple interactive pathways for a single gene, NFkB.  Bioinformation. 2012;8(9):399-402. [PMID: 22715307].
  2. Hussain AR, et al. Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis. PLoS One. 2012;7(6):e39945. [PMID: 22768179].
  3. Morita M, et al. Advanced glycation end products-induced reactive oxygen species generation is partly through NF-kappa B activation in human aortic endothelial cells. J Diabetes Complications. 2012 Aug 31. [PMID: 22944044].
  4. Malato Y, et al. NF-κB Essential Modifier is Required for Hepatocyte Proliferation and the Oval Cell Reaction after Partial Hepatectomy in Mice. Gastroenterology. 2012 Aug 22. [PMID: 22922425].
  5. Bianco B, et al. The nuclear factor-kB functional promoter polymorphism is associated with endometriosis and infertility. Hum Immunol. 2012 Aug 16. [PMID: 22902396].

IHC Image of c-Rel IHC Image of FADD IHC Image of IKK alpha IHC Image of TGF beta 1

IHC analysis of c-Rel
in human breast
carcinoma tissue using NBP1-62000.

IHC analysis of FADD
in human lung
carcinoma tissue using NB100-92032.

IHC analysis of IKK alpha
in human colon
carcinoma tissue using NB100-91824.

IHC analysis of IKK beta
in human breast
carcinoma tissue using
NBP1-95829.

 

IF Image of IKK gamma IHC Image of IL1 beta IF Image of eEF2K IHC Image of IRAK

IF analysis of IKK
gamma in 251MG cells
using NBP1-84681.

IHC analysis of IL1 beta
in human lung carcinoma
tissue using NBP1-19775.

IHC analysis of IL1
Receptor I in mouse lung
using NB110-85471.
IHC analysis of IRAK in
of human thyroid
using NBP1-61700.