NFKB Signaling Pathway

Nuclear factor kappa beta (NFkB) is a nearly ubiquitous pathway responsible for mediating DNA transcription, and therefore cell function. The pathway is activated by a variety of stimuli including cellular stress, cytokines, free radicals, UV radiation, oxidized LDL, and bacterial/viral infection.

Activated NFkB is translocated to the nucleus where it binds to specific sequences of DNA called response elements. This DNA/NFkB complex then recruits RNA polymerase and other coactivators, which transcribe downstream DNA into mRNA, for protein synthesis.

NFKB Pathway

Explore Your Pathways With Novus Explorer! This free bioinformatics tool is designed to facilitate scientific exploration of related genes, diseases and pathways based on co-citations.

Novus Biologicals offers a number of high quality antibodies and other products for the NFkB signaling pathway. Some of our most popular products for this research area are listed below.

Popular Antibodies for NFkB Signaling

 

Inhibitors for NFkB Signaling

AKT1

NB100-56631

 

NFkB p105/p50 Inhibitor Peptide Set 

NBP2-29323

AKT1/2 [p Ser473]

NB100-56749

 

IKK gamma Inhibitor Peptide Set

NBP2-26504

c-Rel

NBP2-37593

 

RelA/NFkB p65 [p Ser276] Inhibitor Peptide Set 

NBP2-26505

IKK alpha

NB100-56704

 

RelA/NFkB p65 [p Ser529, p Ser536] Inhibitor Peptide Set 

NBP2-29321

 IKK alpha/beta

NBP1-61306

 

MyD88 Inhibitor Peptide Set 

NBP2-29328

IKK beta

NB100-56513

 

Curcumin 

NBP2-26243

IRAK1 

NB100-56699

 

LPS

NBP2-25295

NFkB p105/p50

 NB100-56583

 

 

 

NFkB p65

 NBP1-96138

 

Cell Lines and Kits for NFkB Signaling

 

NFkB p65 NLS 

 NBP2-24541

 

Human NFkB Secreted Alkaline Phosphatase SEAP - (SEAPorter™) Stable Reporter Cell Line

NBP2-26260

NFkB1/NFkB p105

NBP1-77395

 

Mouse NFkB Secreted Alkaline Phosphatase SEAP - (SEAPorter™) Stable Reporter Cell Line

NBP2-26261

PKC 

NB600-201

 

NFkB p65 (with coated strip plates) ELISA Kit

NBP2-31042

TRAF2

NB100-56715

 

RelA/NFkB p65 ELISA Kit

NBP2-29661

TRAF4

NB100-56177

 

NFkB Secreted Alkaline Phosphatase Assay Kit

NBP2-25286

TRAF6

NB100-56179

 

IkBa Mutant Adenovirus Assay Kit [NBP2-29443]

NBP2-29443

Ubiquitin 

NB300-130

 

Nuclear Extraction Kit

NBP2-29447

 

 

IHC Image of c-Rel IHC Image of FADD IHC Image of IKK alpha/td> IHC Image of TGF beta 1
RelA/NFkB p65 Antibody [NBP1-96138] - Simple Western analysis of 1.0 mg/ml of HeLa cells NFkB p105/p50 Antibody (2J10D7) [NB100-56583] – Western Blot analysis of HeLa cells lysate with/without immunizing peptide. IKK alpha Antibody (14A231) [NB100-56704] – Flow analysis of HEK293 cells using intracellular staining protocol. Ubiquitin Antibody (Ubi-1) [NB300-130] IHC staining of human rectal cancer for Ubiquitin using HRP-DAB & hematoxylin.
         

NFkB Signaling Pathway References

  1. Shapshak P. Bioinformation and molecule of the month: Multiple interactive pathways for a single gene, NFkB.  Bioinformation. 2012;8(9):399-402. [PMID: 22715307].
  2. Hussain AR, et al. Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis. PLoS One. 2012;7(6):e39945. [PMID: 22768179].
  3. Morita M, et al. Advanced glycation end products-induced reactive oxygen species generation is partly through NF-kappa B activation in human aortic endothelial cells. J Diabetes Complications. 2012 Aug 31. [PMID: 22944044].
  4. Malato Y, et al. NF-κB Essential Modifier is Required for Hepatocyte Proliferation and the Oval Cell Reaction after Partial Hepatectomy in Mice. Gastroenterology. 2012 Aug 22. [PMID: 22922425].
  5. Bianco B, et al. The nuclear factor-kB functional promoter polymorphism is associated with endometriosis and infertility. Hum Immunol. 2012 Aug 16. [PMID: 22902396].