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mTOR Antibody (NBP1-36160)

mTOR Antibody

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mTOR Antibody Summary:
Species:Hu
Applications:IHC-P
Clonality:Polyclonal
Gene:MTOR
Purity:Immunogen affinity purified
Host:Rabbit
Specificity:This product is specific for mTOR
 
Note: Not all species have been tested for usefulness with this product. Only those species listed have been tested. We cannot make any guarantees about additional reactivities which may or may not occur.
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mTOR Antibody Details:
Isotype:IgG
Immunogen:A synthetic peptide derived from C-terminus of human mTOR protein
Species Reactivity:

This product is specific for Human.

Applications:
Uses:This product is useful for Immunohistochemistry Paraffin. This product has a prediluted size available.  If a 6mL or 7mL pre-diluted size is purchased this product can be used Neat (without further dilution).  Use recommended dilution for the concentrated vials only.
Dilutions:Immunohistochemistry-Paraffin 1: 1:100
Unit Size:0.1 ml
Concentration:Please see the vial label for concentration.
Notes:
This product has a prediluted size available.  If a 6mL or 7mL pre-diluted size is purchased this product can be used Neat (without further dilution).  Use recommended dilution for the concentrated vials only.
Packaging:
Storage:Store at 4 °C. Do not freeze.
Buffer:10mM PBS, pH 7.4
Preservative:No Preservative
Limitations:This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months.
Gene Symbol: MTOR
Entrez2475 (Human)
 
Background:

The mammalian target of rapamycin (mTOR) is a major effector of cell growth and proliferation via the regulation of protein synthesis. mTOR is composed of an N-term; 20 tandem repeats- HEAT which are implicated in protein-protein interactions and a C-term; which includes a FAT domain, a FBR domain, a kinase domain, a NDR domain and a FATC domain. The FATC domain is essential to mTOR activity and the deletion of a single amino acid from this domain abrogates the activity. mTOR can be auto-phosphorylated via its intrinsic serine/threonine kinase activity. mTOR regulates protein synthesis through the phosphorylation and inactivation of the repressor of mRNA translation 4E-BP1 and though the phosphorylation and activation of S6 kinase. RAPTOR (regulatory associated protein of TOR) is a positive regulator of TOR. Other known mediators of mTOR include PI3-K and ATK from the insulin pathway.
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